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Titolo:
Calcium signaling and cytotoxicity
Autore:
Kass, GEN; Orrenius, S;
Indirizzi:
Univ Surrey, Sch Biol Sci, Guildford GU2 5XH, Surrey, England Univ SurreyGuildford Surrey England GU2 5XH ord GU2 5XH, Surrey, England Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 Med, S-10401 Stockholm, Sweden
Titolo Testata:
ENVIRONMENTAL HEALTH PERSPECTIVES
, volume: 107, anno: 1999, supplemento:, 1
pagine: 25 - 35
SICI:
0091-6765(199902)107:<25:CSAC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; CYTOSOLIC CA-2+ CONCENTRATION; PERMEABILITY TRANSITION PORE; CCAAT REGULATORY ELEMENT; ISOLATED RAT HEPATOCYTES; FREE CA2+ CONCENTRATION; ICE FAMILY PROTEASES; MOUSE LYMPHOMA-CELLS; INTRACELLULAR CALCIUM;
Keywords:
apoptosis; necrosis; Ca2+-ATPase; inositol 1,4,5-trisphosphate; Ca2+ influx; thapsigargin; caspase; calpains; permeability transition; mitochondria;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
179
Recensione:
Indirizzi per estratti:
Indirizzo: Kass, GEN Univ Surrey, Sch Biol Sci, Guildford GU2 5XH, Surrey, England Univ Surrey Guildford Surrey England GU2 5XH H, Surrey, England
Citazione:
G.E.N. Kass e S. Orrenius, "Calcium signaling and cytotoxicity", ENVIR H PER, 107, 1999, pp. 25-35

Abstract

The divalent calcium cation Ca2+ is used as a major signaling molecule during cell signal transduction to regulate energy output, cellular metabolism, and phenotype. The basis to the signaling role of Ca2+ is an intricate network of cellular channels and transporters that allow a low resting concentration of Ca2+ in the cytosol of the cell ([Ca2+](i)) but that are also coupled to major dynamic and rapidly exchanging stores. This enables extracellular signals from hormones and growth factors to be transduced as [Ca2+](i) spikes that are amplitude and frequency encoded. There is considerable evidence that a number of toxic environmental chemicals target these Ca2+ signaling processes, alter them, and induce cell death by apoptosis. Two majorpathways for apoptosis will be considered. The first one involves Ca2+-mediated expression of ligands that bind to and activate death receptors such as CD95 (Fas, APO-1), in the second pathway, Ca2+ has a direct toxic effectand its primary targets include the mitochondria and the endoplasmic reticulum (ER). Mitochondria may respond to an apoptotic Ca2+ signal by the selective release of cytochrome c or through enhanced production of reactive oxygen species and opening of an inner mitochondrial membrane pore. Toxic agents such as the environmental pollutant tributyltin or the natural plant product thapsigargin, which deplete the ER Ca2+ stores, will induce as a direct result of this effect the opening of plasma membrane Ca2+ channels and an ER stress response. In contrast, under some conditions, Ca2+ signals may be cytoprotective and antagonize the apoptotic machinery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:04:08