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Titolo:
Clinical presentation and early course of type 1 diabetes in patients withand without thyroid autoimmunity
Autore:
Fernandez-Castaner, M; Gomez, JM; Molina, A; Soler, J; Lopez-Jimenez, L;
Indirizzi:
CSUpainlvitge, Endocrine Unit, Lhospitalet De Llobregat 08907, Barcelona, S CSU Bellvitge Lhospitalet De Llobregat Barcelona Spain 08907 Barcelona, S
Titolo Testata:
DIABETES CARE
fascicolo: 3, volume: 22, anno: 1999,
pagine: 377 - 381
SICI:
0149-5992(199903)22:3<377:CPAECO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POOR METABOLIC CONTROL; BETA-CELL FUNCTION; ISLET-CELL; MELLITUS; IDDM; ANTIBODIES; DIAGNOSIS; CHILDREN; DISEASE; AUTOANTIBODIES;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandez-Castaner, M CSU8907,vitge, Endocrine Unit, Feixa Llarga S-N, Lhospitalet De Llobregat 0 CSU Bellvitge Feixa Llarga S-N Lhospitalet De Llobregat Barcelona Spain 08907
Citazione:
M. Fernandez-Castaner et al., "Clinical presentation and early course of type 1 diabetes in patients withand without thyroid autoimmunity", DIABET CARE, 22(3), 1999, pp. 377-381

Abstract

OBJECTIVE - To evaluate the prevalence of thyroid autoimmunity (TAI) in patients with recent-onset type 1 diabetes and to determine the influence of TAI on the clinical presentation and evolution of type 1 diabetes. RESEARCH DESIGN AND METHODS - We studied 111 newly diagnosed type 1 diabetes patients >13 years old. The diagnosis of TAI was based on medical history and measurement of thyroid peroxidase (microsomal) antibodies (TPOAs). Clinical presentation of diabetes, beta-cell autoimmune markers (GADAs and IA2As), and evolution of insulin-secretory reserves and metabolic control during the first 2 years of follow-up were analyzed. Differences between groups were evaluated by Student's t test or the chi(2) test. The influence of TAI on follow-up data was evaluated by multiple logistic regression analysis. RESULTS - TAI was present in 31 patients (14 TPOA(+) patients with normal thyroid function, 12 TPOA(+) patients with thyroid dysfunction, and 5 patients with previously diagnosed TAI). TAI was more prevalent in women than inmen (43.7 vs. 15.9%, P = 0.001). beta-Cell autoimmunity was more prevalentin patients with TAI than in those without TAI (93.5 vs. 76.3%, P = 0.03). The evolution of insulin requirements, metabolic control, and insulin-secretory reserves was comparable in the two groups. CONCLUSIONS - TAI is present in many type 1 diabetes patients at the time of diagnosis and is associated with a high prevalence of thyroid dysfunction. The clinical presentation of diabetes and the evolution of metabolic control and insulin-secretory reserves are not influenced by the presence of TAI. Patients with type 1 diabetes should be screened for TAI at diagnosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:04:41