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Titolo:
Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes - The 2-year analysis of the German BABYDIAB study
Autore:
Ziegler, AG; Hummel, M; Schenker, M; Bonifacio, E;
Indirizzi:
Diabet Res Inst, D-80804 Munich, Germany Diabet Res Inst Munich Germany D-80804 Res Inst, D-80804 Munich, Germany Stadt Krankenhaus Munchen Schwabing, Dept Med 3, Munich, Germany Stadt Krankenhaus Munchen Schwabing Munich Germany d 3, Munich, Germany San Raffaele Sci Inst, I-20132 Milan, Italy San Raffaele Sci Inst Milan Italy I-20132 Sci Inst, I-20132 Milan, Italy
Titolo Testata:
DIABETES
fascicolo: 3, volume: 48, anno: 1999,
pagine: 460 - 468
SICI:
0012-1797(199903)48:3<460:AAARFD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLET-CELL ANTIBODIES; GLUTAMIC-ACID DECARBOXYLASE; FIRST-DEGREE RELATIVES; INSULIN; IDDM; AUTOIMMUNITY; PREDICTION; BINDING; MARKERS; MOTHERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Ziegler, AG Diabet Res Inst, Koelner Pl 1, D-80804 Munich, Germany Diabet Res Inst Koelner Pl 1 Munich Germany D-80804 , Germany
Citazione:
A.G. Ziegler et al., "Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes - The 2-year analysis of the German BABYDIAB study", DIABETES, 48(3), 1999, pp. 460-468

Abstract

The temporal development of autoantibodies was studied in 1,353 offspring of parents with type 1 diabetes. Islet cell antibodies (ICAs) and autoantibodies to insulin (IAAs), glutamic acid decarboxylase, and IA-2 were measured at birth, 9 months, 2 years, and 5 years of age. At birth, no offspring had islet autoimmunity other than maternally acquired antibodies, which wereshown to influence antibody prevalence up to age 6 months. Antibodies detected thereafter were likely to represent a true de novo production, since prevalences were the same for offspring from mothers and fathers with diabetes, antibodies detected at 9 months were almost always confirmed in the S-year sample and were associated with an increased Likelihood of having or developing other antibodies. By 2 Sears of age, autoantibodies appeared in 11% of offspring, 3.5% having more than one autoantibody IAAs were detected most frequently and few had autoantibodies in the absence of IAAs. in 23 offspring with multiple islet autoantibodies, IAAs preceded other antibodies in 10 cases and were first detected concurrently with other antibodies in 12and after detection of other antibodies in 1. Development of additional antibodies and changes in levels, including decline of IAAs at older age, wasfrequent. Nine children, all with IAAs and ICAs, developed diabetes. Overall cumulative risk for disease by 5 years of age was 1.8% (95% CI 0.2-3.4) and was 50% (95% CI 19-81) for offspring with more than one autoantibody intheir 2-year sample. Autoimmunity associated with childhood diabetes is anearly event and a dynamic process. Presence of IAAs is a consistent feature of this autoimmunity, and IAA detection can identify children at risk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:14:45