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Titolo:
Cytokine release from placental endothelial cells, a process associated with preterm labour in the absence of intrauterine infection
Autore:
Steinborn, A; Niederhut, A; Solbach, C; Hildenbrand, R; Sohn, C; Kaufmann, M;
Indirizzi:
Univ Frankfurt, Dept Obstet Gynecol, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 col, D-60590 Frankfurt, Germany Univ Frankfurt, Dept Pathol, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 hol, D-60590 Frankfurt, Germany
Titolo Testata:
CYTOKINE
fascicolo: 1, volume: 11, anno: 1999,
pagine: 66 - 73
SICI:
1043-4666(199901)11:1<66:CRFPEC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; AMNIOTIC-FLUID INTERLEUKIN-6; IMMUNOHISTOCHEMICAL LOCALIZATION; HISTOLOGIC CHORIOAMNIONITIS; INFLAMMATORY MEDIATORS; INTACT MEMBRANES; FACTOR-ALPHA; GRAM STAIN; TERM; PARTURITION;
Keywords:
endothelial cells; immunohistochemistry; inflammatory cytokines; intra-amniotic infection; preterm labour;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Steinborn, A Univ,Frankfurt, Dept Obstet Gynecol, Theodor-Stern-Kai 7, D-60590 Frankfurt Univ Frankfurt Theodor-Stern-Kai 7 Frankfurt Germany D-60590
Citazione:
A. Steinborn et al., "Cytokine release from placental endothelial cells, a process associated with preterm labour in the absence of intrauterine infection", CYTOKINE, 11(1), 1999, pp. 66-73

Abstract

There is currently a great deal of interest in the role that cytokines mayplay in the processes mediating preterm as well as normal term labour. In case of preterm delivery a cause-effect relationship between infection, uncontrollable preterm labour, and increased uterine cytokine concentrations is widely accepted, but there is considerable information that increased uterine cytokine release is also a condition in normal term labour and pretermlabour not due to infection. Thereby, the exact cellular sources of cytokine production have not yet been identified. In the present study, the authors used immunohistochemical analysis to localize interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-alpha) immunoreactivity within trophoblastic villi and fetal membranes. In the absence of chorioamnionitis, uncontrollable preterm labour, and also normal term labour was associated with strong immunoreactivity for IL-1 beta and IL-6 in the endothelial cells within trophoblastic villi. In contrast, preterm delivery accompanied by histologically confirmed chorioamnionitis, was not associated with increased expression of cytokine antigens within endothelial cells of the fetal vascular system, but strong cytokine activity was found in polymorphonuclear cells infiltrating the amniochorionic membranes. Therefore, the data suggest two well-defined subgroups among patients deliveringpreterm. Thereby, increased uterine cytokine concentrations may be realized in both groups, but the,cellular sources of cytokine production may be different. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 07:48:43