Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Immunoblot and immunoelectronmicroscopic analysis of endemic Tunisian pemphigus
Autore:
Joly, P; Mokhtar, I; Gilbert, D; Thomine, E; Fazza, B; Bardi, R; Lauret, P; Ayed, K; Tron, F; Kamoun, MR;
Indirizzi:
Ctrnopathol,IFRharlesen,colle, Dermatol Clin, Fac Med & Pharm,Grp Rech Immu Ctr Hosp Univ Charles Nicolle Rouen France F-76031 & Pharm,Grp Rech Immu Ctr Hosp Univ Charles Nicolle, Immunol Lab, Dermatol Clin, Tunis, Tunisia Ctr Hosp Univ Charles Nicolle Tunis Tunisia rmatol Clin, Tunis, Tunisia
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 1, volume: 140, anno: 1999,
pagine: 44 - 49
SICI:
0007-0963(199901)140:1<44:IAIAOE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-SURFACE ANTIBODY; PARANEOPLASTIC PEMPHIGUS; DESMOSOMAL PLAQUE; FOLIACEUS; VULGARIS; ANTIGEN; WOMEN;
Keywords:
antibody binding properties; endemic Tunisian pemphigus; immunoblot analysis; immunoelectron microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Joly, P Ctrnopathol,IFRharlesen,colle, Dermatol Clin, Fac Med & Pharm,Grp Rech Immu Ctr Hosp Univ Charles Nicolle Rouen France F-76031 Grp Rech Immu
Citazione:
P. Joly et al., "Immunoblot and immunoelectronmicroscopic analysis of endemic Tunisian pemphigus", BR J DERM, 140(1), 1999, pp. 44-49

Abstract

Tunisian pemphigus is a newly described form of endemic pemphigus whose clinical, histological and epidemiological characteristics have recently beendetailed. The objective of this study was to analyse the binding properties of autoantibodies present in sera from patients with endemic Tunisian pemphigus using immunoblotting and indirect immunoelectron microscopy (IEM). Thirty patients with pemphigus foliaceus (PF) and six with pemphigus vulgaris (PV) seen in the dermatology department of Tunis Hospital between 1992 and 1994 were selected for this study. Seven of 30 (23%) and six of 12 (50%) PF sera tested bound to the 160 kDa band of desmoglein 1 when tested on bovine tongue and human epidermal extracts, respectively. Two of six and two of three PV sera tested bound to the 130 kDa desmoglein 3 in these two extracts. Immunoblot and indirect IEM showed that 24 of 30 (80%) PF sera contained IgG1, IgG3 or IgG4 antibodies that bound to a 185-kDa polypeptide localized on the desmosomal plaque. This immunological analysis showed that most endemic Tunisian pemphigus sera correspond to PF sera and are characterizedby a high frequency of autoantibodies directed against a recently identified 185-kDa antigen of the desmosomal plaque.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:56:48