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Titolo:
Striatal grafts alleviate deficits in response execution in a lateralised reaction time task
Autore:
Dobrossy, MD; Dunnett, SB;
Indirizzi:
Univ Cambridge, MRC, Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY air, Cambridge CB2 2PY, England Univ Cambridge, Dept Expt Psychol, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY hol, Cambridge CB2 2PY, England
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 6, volume: 47, anno: 1998,
pagine: 585 - 593
SICI:
0361-9230(199812)47:6<585:SGADIR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOICE-REACTION-TIME; SKILLED FORELIMB USE; ADULT-RAT BRAIN; DOPAMINE DEPLETION; TYROSINE-HYDROXYLASE; HUNTINGTONS-DISEASE; NEURAL TRANSPLANTS; DONOR STAGE; PERFORMANCE; LESIONS;
Keywords:
neural transplantation; striatal lesions; striatal grafts; cortical grafts; rats; ibotenic acid; reaction time; choice reaction time; movement time;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Dunnett, SB UnivCambridgee, MRC, Cambridge Ctr Brain Repair, Forvie Site,Robinson Way, Univ Cambridge Forvie Site,Robinson Way Cambridge England CB22PY
Citazione:
M.D. Dobrossy e S.B. Dunnett, "Striatal grafts alleviate deficits in response execution in a lateralised reaction time task", BRAIN RES B, 47(6), 1998, pp. 585-593

Abstract

It has been reported that homotopic neural transplants can ameliorate behavioural impairments induced by striatal lesions in a reaction time (RT) task, In the present study we seek to replicate and extend this observation ina new lateralised choice RT task based on the conventional Skinner box apparatus. Rats were trained to make rapid lateralised lever press responses to a visual stimulus presented on either the left or the right side of the animal. The RTs required to initiate and execute correct responses were recorded, along with other accuracy and performance indices. Following unilateral lesions of the dorsal striatum, the rats exhibited an increased number of error trials, a bias to respond towards the ipsilateral side, a decreasedaccuracy on the contralateral side, and an increase of the execution time to respond correctly to contralateral stimuli. Striatal grafts alleviated the lateralised response deficits, prevented the development of lateral disparity, and restored the speed of responding back to pre-lesion levels. Control grafts of cortical tissues also increased task accuracy and reduced theipsilateral bias in responding, but were without effect on the RT deficit. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:42:19