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Titolo:
Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: A comparison with bone marrow and autologous cortical bone implantation
Autore:
Sebecic, B; Nikolic, V; Sikiric, P; Seiwerth, S; Sosa, T; Patrlj, L; Grabarevic, Z; Rucman, R; Petek, M; Konjevoda, P; Jadrijevic, S; Perovic, D; Slaj, M;
Indirizzi:
Clin Hosp Merkur, Dept Surg, Zagreb, Croatia Clin Hosp Merkur Zagreb Croatia Hosp Merkur, Dept Surg, Zagreb, Croatia Univ Zagreb, Med & Vet Fac, Dept Pharmacol, Zagreb 41000, Croatia Univ Zagreb Zagreb Croatia 41000 , Dept Pharmacol, Zagreb 41000, Croatia Univ Zagreb, Med & Vet Fac, Dept Anat & Pathol, Zagreb 41000, Croatia UnivZagreb Zagreb Croatia 41000 pt Anat & Pathol, Zagreb 41000, Croatia
Titolo Testata:
BONE
fascicolo: 3, volume: 24, anno: 1999,
pagine: 195 - 202
SICI:
8756-3282(199903)24:3<195:OEOAGP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ILIAC BONE; DONOR-SITE; MORPHOGENETIC PROTEIN; LESIONS; STRESS; COMPLICATION; GASTRECTOMY; FRACTURE; PEPTIDE; CELLS;
Keywords:
gastric pentadecapeptide BPC-157; intramuscular application; local application; osteogenic effect; bone marrow; autologous cortical bone; implantation; segmental bone defects; rabbits; stomach;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Sikiric, P Univtiagreb, Fac Med, Dept Pharmacol, Salata 11,POB 916, Zagreb10000, Croa Univ Zagreb Salata 11,POB 916 Zagreb Croatia 10000 10000, Croa
Citazione:
B. Sebecic et al., "Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: A comparison with bone marrow and autologous cortical bone implantation", BONE, 24(3), 1999, pp. 195-202

Abstract

Gastrectomy often results in increased likelihood of osteoporosis, metabolic aberration, and risk of fracture, and there is a need for a gastric peptide with osteogenic activity. A novel stomach pentadecapeptide, BPC-157, improves wound and fracture healing in rats in addition to having an angiogenic effect Therefore, in the present study, using a segmental osteoperiosteal bone defect (0.8 cm, in the middle of the left radius) that remained incompletely healed in all control rabbits for 6 weeks (assessed in 2 week intervals), pentadecapeptide BPC-157 was further studied (either percutaneouslygiven locally [10 mu g/kg body weight] into the bone defect, or applied intramuscularly [intermittently, at postoperative days 7, 9, 14, and 16 at 10mu g/kg body weight] or continuously [once per day, postoperative days 7-21 at 10 mu g or 10 ng/kg body weight]), For comparison, rabbits percutaneously received locally autologous bone marrow (2 mt, postoperative day 7), Asstandard treatment, immediately after its formation, the bone defect was filled with an autologous cortical graft. Saline-treated (2 mL intramuscularly [i.m.] and 2 mL locally into the bone defect), injured animals were usedas controls. Pentadecapeptide BPC-157 significantly improved the healing of segmental bone defects. For instance, upon radiographic assessment, the callus surface, microphotodensitometry, quantitative histomorphometry (10 mug/kg body weight i.m. for 14 days), or quantitative histomorphometry (10 ng/kg body weight i.m. for 14 days) the effect of pentadecapeptide BPC-157 was shown to correspond to improvement after local application of bone marrow or autologous cortical graft, Moreover, a comparison of the number of animals with unhealed defects (all controls) or healed defects (complete bony continuity across the defect site) showed that besides pentadecapeptide intramuscular application for 14 days (i.e., local application of bone marrow or autologous cortical graft), also following other pentadecapeptide BPC-157 regimens (local application, or intermittent intramuscular administration), the number of animals with healed defect was increased. Hopefully, in the light of the suggested stomach significance for bone homeostasis, the possible relevance of this pentadecapeptide BPC-157 effect (local or intramuscular effectiveness, lack of unwanted effects) could be a basis for methods of choice in the future management of healing impairment in humans, and requires further investigation, (Bone 24:195-202; 1999) (C) 1999 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 14:19:14