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Titolo:
Apolipoprotein E-epsilon 4 frequency in affective disorder
Autore:
Kessing, LV; Jorgensen, OS;
Indirizzi:
Univ Copenhagen, Dept Psychiat, Rigshosp, DK-2100 Copenhagen O, Denmark Univ Copenhagen Copenhagen Denmark O hosp, DK-2100 Copenhagen O, Denmark Univ Copenhagen, Lab Neuropsychiat, Rigshosp, DK-2100 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 45, anno: 1999,
pagine: 430 - 434
SICI:
0006-3223(19990215)45:4<430:AE4FIA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE-ONSET DEPRESSION; ALZHEIMERS-DISEASE; TYPE-4 ALLELE; EPSILON-4; DEMENTIA; ASSOCIATION; RISK;
Keywords:
affective disorder; dementia; Alzheimer's disease; cognition; apolipoprotein E; recurrence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kessing, LV Univ Copenhagen, Dept Psychiat, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen Univ Copenhagen Blegdamsvej 9 Copenhagen Denmark O Copenhagen
Citazione:
L.V. Kessing e O.S. Jorgensen, "Apolipoprotein E-epsilon 4 frequency in affective disorder", BIOL PSYCHI, 45(4), 1999, pp. 430-434

Abstract

Background:The epsilon 4 allele of apolipoprotein E (APOE) as well as affective disorder have been found to be associated with Alzheimer's disease, but it is unclear whether cognitive impairment in affective disorder or subtypes of affective disorder is mediated by the epsilon 4 allele of APOE. Methods: The genotype of APOE tr as analyzed in 106 unipolar patients, 21 bipolar patients, and 46 controls and correlated with cognitive function inthe euthymic phase as measured by the Mini-Mental State Examination, the Cambridge Cognitive Examination the Mattis Dementia Rating Scale, the Gottfries-Brane-Steen Dementia Raring Scale, and the Global Deterioration Scale. Results: The frequency of APOE-epsilon 4 allele was approximately the samein unipolar patients (.189) and in bipolar patients (.167). Although patients showed more cognitive impairment than controls, no significant overall difference was Sound between the frequency of APOE-epsilon 4 allele in patients (.185) and controls (.131). In fact, the frequency of APOE-epsilon 4 allele did nor correlate with cognitive impairment. It was not possible to identify subgroups of patients with an increased frequency of APOE-epsilon 4allele, as no association was found with gender, age at onset, the number of affective episodes, the presence of psychotic features, or the prevalence of familial affective disorder. Conclusions: It seems that cognitive impairment in affective disorder can be attributed to pathways other than the APOE genotype. (C) 1999 Society ofBiological Psychiatry.

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Documento generato il 31/03/20 alle ore 22:44:55