Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparative efficacy of olanzapine and haloperidol for patients with treatment-resistant schizophrenia
Autore:
Breier, A; Hamilton, SH;
Indirizzi:
Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USAEli Lilly & Co Indianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 45, anno: 1999,
pagine: 403 - 411
SICI:
0006-3223(19990215)45:4<403:CEOOAH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFRACTORY SCHIZOPHRENIA; PSYCHOTIC DEPRESSION; CLOZAPINE TREATMENT; TARDIVE-DYSKINESIA; COST-EFFECTIVENESS; NEGATIVE SYMPTOMS; SERUM PROLACTIN; TRIAL; MANAGEMENT; PLACEBO;
Keywords:
olanzapine; haloperidol; treatment-resistant schizophrenia; nonresponders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Breier, A Elis,illy & Co, Lilly Corp Ctr, Lilly Res Labs, Drop Code 0538, Indianapoli Eli Lilly & Co Drop Code 0538 Indianapolis IN USA 46285 ianapoli
Citazione:
A. Breier e S.H. Hamilton, "Comparative efficacy of olanzapine and haloperidol for patients with treatment-resistant schizophrenia", BIOL PSYCHI, 45(4), 1999, pp. 403-411

Abstract

Background: There is relatively little information regarding the efficacy of newer atypical antipsychotic drugs for patients with schizophrenia who are treatment-resistant to neuroleptic agents. Several lines of evidence suggest that a clinical trial of olanzapine in this population is warranted. Methods: A subpopulation of patients (n = 526) meeting treatment-resistantcriteria selected from? a large, prospective, double-blind, 6-week study assessing the efficacy and safety of olanzapine and haloperidol were examined Both last-observation-carried-forward (LOCF) and completers (observed cases) analyses were conducted. Results: Olanzapine demonstrated significantly greater mean improvement from baseline in Positive and Negative Syndrome Scale (PANSS) negative symptoms, comorbid depressive symptoms assessed by the Montgomery-Asberg Depression Rating Scale, akathisia as measured by Barnes Akathisia Scale, and extrapyramidal symptoms as measured by Simpson-Angus Extrapyramidal Rating Scalewith both LOCF and completers analyses. In addition, olanzapine was significantly superior to haloperidol for Brief Psychiatric Rating Scale total (p=.006), PANSS total (p =.005), and PANSS positive symptoms (p =.017) in completers of the ti-week study. Significantly greater response rates were observed in olanznpine-treated (47%) than haloperidol-treated (35%) patients in the LOCF analysis (p =.008), but significance was not reached in the completers analysis (p =.093), Mean doses (+/-SD) of olanzapine and haloperidol were II,I +/- 3.4 mg/day and 10.0 +/- 3.6 mg/day, respectively. Conclusions: Olanzapine was superior to haloperidol for key symptom domains and parkinsonian side effects. Implications of these data for the therapeutics of this severely ill subgroup are discussed. (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:04:51