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Titolo:
Conditioned increase in place preference by access to novel objects: antagonism by MK-801
Autore:
Bevins, RA; Bardo, MT;
Indirizzi:
Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA Univ Nebraska Lincoln NE USA 68588 a, Dept Psychol, Lincoln, NE 68588 USA Univ Kentucky, Dept Psychol, Lexington, KY 40506 USA Univ Kentucky Lexington KY USA 40506 ept Psychol, Lexington, KY 40506 USA
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 99, anno: 1999,
pagine: 53 - 60
SICI:
0166-4328(19990215)99:1<53:CIIPPB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA-RECEPTOR ANTAGONIST; RATS; ACQUISITION; NOVELTY; AMPHETAMINE; DIZOCILPINE; MORPHINE; BEHAVIOR; COCAINE; VULNERABILITY;
Keywords:
cocaine; dizocilpine; glutamate; pavlovian conditioning; NMDA; novelty; reward;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Bevins, RA Univ Nebraska, Dept Psychol, Burnett Hall, Lincoln, NE 68588 USA Univ Nebraska Burnett Hall Lincoln NE USA 68588 n, NE 68588 USA
Citazione:
R.A. Bevins e M.T. Bardo, "Conditioned increase in place preference by access to novel objects: antagonism by MK-801", BEH BRA RES, 99(1), 1999, pp. 53-60

Abstract

In three separate place conditioning experiments with rats, repeated access to novel objects in one of two distinct environments conditioned an increase in preference for the novelty-paired environment. A conditioned increase in preference was found whether novel objects were paired with a randomlychosen environment or with the less preferred of two environments (conditioned against a preference). This enhanced preference did not depend on the control group employed. Control groups exposed only to the place conditioning apparatus or to both the apparatus and the novel objects showed no systematic shift in place preference. Intravenous infusions of cocaine also produced an increase in preference using the procedures employed with novel objects. Pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonistMK-801 (0.03 mg kg(-1)) blocked acquisition of the enhanced place preference conditioned by access to novel objects without decreasing time spent with objects or inducing a place aversion in controls. Combined, these resultsshow that access to novel objects can serve as an appetitive stimulus likedrugs of abuse and that this novelty-induced appetitive process involves NMDA receptors. These place-conditioning procedures may provide a good modelfor determining the behavioral and neural process underlying the appetitive effects of novelty. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 02/04/20 alle ore 21:33:09