Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Radiopharmacokinetics, renal clearance and dosimetry of Tc-99m-MAG(3)
Autore:
de Murphy, CA; Molina-Trinidad, E; Melendez-Alafort, L; Ferro-Flores, G; Reyes-Herrera, L; Sepulveda-Mendez, J; Sandoval-Guzman, B; Hoyo-Vadillo, C;
Indirizzi:
Inst Nacl Nutr Salvador Zubiran, Dept Nucl Med & Clin Tiroides, Mexico City Inst Nacl Nutr Salvador Zubiran Mexico City DF Mexico 14000 , Mexico City Univ,Nacl Autonoma Mexico, Div Estudios Posgrado Biofarm, Mexico City 04510 Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 , Mexico City 04510 InstF,acl Invest Nucl, Dept Reactor & Mat Radiactivos, Mexico City 11801, D Inst Nacl Invest Nucl Mexico City DF Mexico 11801 s, Mexico City 11801, D CINVESTAV,tecnt Farmacol & Toxicol, Ctr Invest & Estud Avanzados, Inst Poli CINVESTAV Mexico City DF Mexico Ctr Invest & Estud Avanzados, Inst Poli
Titolo Testata:
ARCHIVES OF MEDICAL RESEARCH
fascicolo: 1, volume: 30, anno: 1999,
pagine: 49 - 54
SICI:
0188-4409(199901/02)30:1<49:RRCADO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TECHNETIUM-99M MAG3; KIT FORMULATION; BIODISTRIBUTION; VOLUNTEERS; ADULTS;
Keywords:
technetium-99m-mercaptoacetyltriglycine; Radiopharmacokinetic clearance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: de Murphy, CA Instgaacl Nutr Salvador Zubiran, Dept Nucl Med & Clin Tiroides, Vasco Quiro Inst Nacl Nutr Salvador Zubiran Vasco Quiroga 15,Delegac Tlalpan Mexico City DF Mexico 14000
Citazione:
C.A. de Murphy et al., "Radiopharmacokinetics, renal clearance and dosimetry of Tc-99m-MAG(3)", ARCH MED R, 30(1), 1999, pp. 49-54

Abstract

Background. Technetium-99m-mercaptoacetyltriglycine ((TC)-T-99m-MAG(3)) isa radiopharmaceutical for tubular function and can be prepared with 99m-technetium and the ligand Bz-MAG(3) (Instituto Nacional de Investigaciones Nucleares, Mexico City). No radiopharmacokinetic parameters have been found for the healthy adult Mexican population with Tc-99m-MAG(3), prepared with the nationally produced or imported Bz-MAG(3) kit. Methods, The radiopharmacokinetic parameters and the clearance of Tc-99m-MAG(3) in seven healthy Mexican volunteers were determined by the single- and multi-sample methods, Computer programs were used for the calculations. Results. Using several plasma samples from 0-43 min and the BIEXP program,it was shown that (TC)-T-99m-MAG(3) follows a two-compartment model of distribution, with an apparent volume in the central compartment Vd(cc) 3.8 + 0.7 l, a volume of distribution at steady state Vd(ss) 6.7 + 1.01, T-1/2 alpha = 0.07 + 0.02 h(-1), T-1/2 beta = 0.49 + 0.15 h(-1), mean residence time MRT = 0.60 + 0.17 h and clearance = 208 + 57 (ml/min)/1.73 m(2). In comparison, the clearance value with a single sample drawn 33 min post-injectionand cal culated with Tauxe's formula was 193 +/- 59 (ml/min)/m(2)Conclusions. The 15 mi difference between the two methods is neither statistically different (p = 0.11) nor important for routine clinical studies. The single-sample method is recommended because it is reliable and can be done at the same time that the dynamic renal scan is acquired. Estimated absorbed radiation dose was calculated for several organs. (C) 1999 IMSS. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:17:54