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Titolo:
Cerebral blood flow velocity during neonatal seizures
Autore:
Boylan, GB; Panerai, RB; Rennie, JM; Evans, DH; Rabe-Hesketh, S; Binnie, CD;
Indirizzi:
Univndondon Kings Coll Hosp, Neonatal Intens Care Unit, Dept Child Hlth, Lo Univ London Kings Coll Hosp London England SE5 9RS , Dept Child Hlth, Lo Inst Psychiat, Dept Clin Neurophysiol, London, England Inst Psychiat London England t, Dept Clin Neurophysiol, London, England Inst Psychiat, Dept Biostat & Comp, London, England Inst Psychiat LondonEngland hiat, Dept Biostat & Comp, London, England Univ Leicester, Dept Med Phys, Leicester LE1 7RH, Leics, England Univ Leicester Leicester Leics England LE1 7RH er LE1 7RH, Leics, England
Titolo Testata:
ARCHIVES OF DISEASE IN CHILDHOOD
fascicolo: 2, volume: 80, anno: 1999,
pagine: F105 - F110
SICI:
0003-9888(199903)80:2<F105:CBFVDN>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTO-REGULATION; PRESSURE; FAILURE;
Keywords:
seizures; EEG; cerebral blood flow velocity; transcranial Doppler;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Rennie, JM Univnmarkon Kings Coll Hosp, Neonatal Intens Care Unit, Dept Child Hlth, De Univ London Kings Coll Hosp Denmark Hill,4th Floor Ruskin WingLondon England SE5 9RS
Citazione:
G.B. Boylan et al., "Cerebral blood flow velocity during neonatal seizures", ARCH DIS CH, 80(2), 1999, pp. F105-F110

Abstract

Aim-To determine if cerebral blood flow velocity increases during all types of neonatal seizure, and whether the effect is due solely to an increase in blood pressure, transmitted to the cerebral circulation when autoregulation is impaired. Methods-Seizures were diagnosed in 11 high risk neonates using cotside 16 channel video-EEG polygraphy. EEG, cerebral blood flow velocity (CBFV) using transcranial Doppler ultrasound, and arterial blood pressure (ABP) measurements were made. At least two 5-10 minute epochs of simultaneous measurements were performed on each infant. These epochs were then reviewed to eliminate artefacts, and one minute data periods containing a clear seizure onset were created. Each period contained 20 seconds before the seizure. Data periods without seizures from the same infants were also analysed and compared with seizure periods. Results-Four infants had purely electrographic seizures-without clinical manifestations. Six infants had electroclinical seizures. One infant displayed both seizure types. A random effects linear regression analysis was usedto determine the effect of seizures on CBFV and ABP. A significant increase was found in mean CBFV in those periods containing seizures. The mean percentage change in velocity for all infants was 15.6%. Three infants showed a significant increase in mean ABP after seizures but the overall increase in ABP for all infants was not significant. Conclusion-Electroclinical and electrographic neonatal seizures produce anincrease in CBFV. In some infants the increase is not associated with an increase in blood pressure. These preliminary results suggest that electrographic seizures are associated with disturbed cerebral metabolism. Treatmentof neonatal seizures until electrographic seizure activity is abolished may improve outcome for these infants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:21:26