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Titolo:
STATIC AND DYNAMIC-RESPONSES OF RENAL CHEMORECEPTOR NEURONS TO INTRAPELVIC PRESSURE INCREASES IN THE RAT
Autore:
MOSS NG; KARASTOIANOVA IV;
Indirizzi:
UNIV N CAROLINA,DEPT PHYSIOL CHAPEL HILL NC 27599
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 3, volume: 63, anno: 1997,
pagine: 107 - 114
SICI:
0165-1838(1997)63:3<107:SADORC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENORENAL REFLEXES; ELECTROPHYSIOLOGICAL CHARACTERISTICS; PELVIC PRESSURE; MECHANORECEPTORS; STIMULATION; AFFERENTS; RECEPTORS; NERVES; KIDNEY; FLOW;
Keywords:
RENAL CHEMORECEPTORS; RENAL PELVIS; KIDNEY NERVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
N.G. Moss e I.V. Karastoianova, "STATIC AND DYNAMIC-RESPONSES OF RENAL CHEMORECEPTOR NEURONS TO INTRAPELVIC PRESSURE INCREASES IN THE RAT", Journal of the autonomic nervous system, 63(3), 1997, pp. 107-114

Abstract

Multiunit afferent renal nerve activity (ARNA) and single unit activity from R2 chemoreceptors were recorded in anesthetized male Sprague Dawley rats during rapid and graded increases in intrapelvic pressure. Multiunit ARNA in 9 rats was excited by rapid intrapelvic pressure increases to 20 mmHg with non-diuretic urine (285.5 +/- 76.2% above control) but not when isotonic saline was used to fill the pelvis (13.0 +/-9.0%). Similar responses were recorded from 27 single R2 chemoreceptors. Multiunit ARNA showed a direct, linear relationship with ramp increases in intrapelvic pressure between 0 and 20 mmHg at rates of 0.05, 0.15 and 0.3 mmHg/s. The responses were dynamically linked to intrapelvic pressure and maximum activations showed a positive linear relationship with the rate of pressure increase. Individual R2 chemoreceptor activity showed a similar dynamic relationship with intrapelvic pressure. ARNA was also excited by intrapelvic backflow of diuretic urine (10% expansion of extracellular volume) but the response in impulses/s was depressed by 58.6 +/- 9% in multiunit preparations and 30.1 +/- 10.8% for R2 chemoreceptors. Basal activities were also reduced during diuresis by 49.0 +/- 16% and 36.7 +/- 12.3% for multiunit and single unitpreparations, respectively, and the percent increases over backgroundduring urine backflow were not different in non-diuresis and diuresis. Both multiunit ARNA and R2 chemoreceptors were also activated by ramp increases in intrapelvic pressure during diuresis, but the dynamic component was lost and responses to each pressure ramp were not different. The similarity in responses between multiunit ARNA and individual R2 chemoreceptors indicates that the multiunit ARNA activation during intrapelvic pressure increases is largely composed of activity from R2chemoreceptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:37:31