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Titolo:
Effect of ticlopidine on streptokinase-induced thrombolysis in rats
Autore:
Gryglewski, RJ; Korbut, R; Swies, J; Uracz, W;
Indirizzi:
Jagiellonian Univ, Coll Med, Chair Pharmacol, PL-31531 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31531 rmacol, PL-31531 Krakow, Poland
Titolo Testata:
WIENER KLINISCHE WOCHENSCHRIFT
fascicolo: 3, volume: 111, anno: 1999,
pagine: 98 - 102
SICI:
0043-5325(19990212)111:3<98:EOTOST>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET ADENYLATE-CYCLASE; TISSUE PLASMINOGEN-ACTIVATOR; ACUTE MYOCARDIAL-INFARCTION; THROMBIN ACTIVITY; NITRIC-OXIDE; ARTERIAL-DISEASE; DOUBLE-BLIND; PROSTACYCLIN; AGGREGATION; THERAPY;
Keywords:
ticlopidine; streptokinase; thrombogenesis; thrombolysis; blood platelets; prostacyclin; early hazard of fibrinolytic therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Gryglewski, RJ Jagielloniankow,v, Coll Med, Chair Pharmacol, 16 Grzegorzecka, PL-31531 Kra Jagiellonian Univ 16 Grzegorzecka Krakow Poland PL-31531 a
Citazione:
R.J. Gryglewski et al., "Effect of ticlopidine on streptokinase-induced thrombolysis in rats", WIEN KLIN W, 111(3), 1999, pp. 98-102

Abstract

Using our original assay system we found that ticlopidine (TP, 30 mg/kg i.v.) had produced a prompt thrombolysis of preformed clots in extracorporealcirculation of anaesthetized rats. In contrast with ticlopidine streptokinase (SK, 30.000 U/kg i.v,) proved thrombogenic for an initial period of 10 - 30 min, followed only later by the expected thrombolytic action. In ticlopidine pretreated rats the thrombogenic effect of streptokinase was eliminated, and its thrombolytic potency intensified. This is the first experimental support for a conception that a combined therapy with ticlopidine and streptokinase may restrict the "early hazard" associated with streptokinase therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:16:26