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Titolo:
Antiintregrins - new antiplatelet agents for prevention and treatment of acute coronary syndrome
Autore:
Schror, K;
Indirizzi:
Univ Dusseldorf, Inst Pharmakol, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany
Titolo Testata:
WIENER KLINISCHE WOCHENSCHRIFT
fascicolo: 3, volume: 111, anno: 1999,
pagine: 90 - 97
SICI:
0043-5325(19990212)111:3<90:A-NAAF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
GER
Soggetto:
PLATELET GLYCOPROTEIN-IIB/IIIA; ACUTE MYOCARDIAL-INFARCTION; MONOCLONAL-ANTIBODIES; RECEPTOR ANTAGONIST; INTEGRIN RECEPTOR; ANGIOPLASTY; PHARMACODYNAMICS; VITRONECTIN; AGGREGATION; INHIBITOR;
Keywords:
atherothrombosis; antiplatelet agents; integrins; GP IIb/IIIa-antagonists; Abciximab;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Schror, K Univ Dusseldorf, Inst Pharmakol, Moorenstr 5, D-40225 Dusseldorf, Germany Univ Dusseldorf Moorenstr 5 Dusseldorf Germany D-40225 Germany
Citazione:
K. Schror, "Antiintregrins - new antiplatelet agents for prevention and treatment of acute coronary syndrome", WIEN KLIN W, 111(3), 1999, pp. 90-97

Abstract

Acute occlusion of a large coronary artery by a platelet thrombus is a life-threatening event. Intravasal thrombus generation in most cases is causedby a disturbed interaction between platelets and the vessel wall, with accompanying platelet hyperreactivity, local adhesion to the vessel wall, activation and aggregate formation after binding of soluble fibrinogen to the activated GP Ilb/IIIa-receptor. Conventional antiplatelet agents, such as aspirin or ticlopidine/clopidogrel, inhibit uncontrolled local agonist-induced signal transduction within the platelet by interfering with the thromboxane Ap and ADP pathway, respectively. This results in an activation of the platelet GP IIb/IIIa-receptor and, finally, in a reduced capacity of fibrinogen binding. Antiintegrins inhibit cell-cell and cell-matrix interactions. Antagonists of the platelet integrin alpha IIB/beta 3 (GP IIb/IIIa) leg. Abciximab, Eptifibatide, Tirofiban inhibit platelet adhesion and aggregation via their RGD (KGD) binding sequence, resulting in reduced fibrinogen binding. The significance of inhibition of other RGD-containing adhesion molecules (von Willebrand Factor, Vitronectin) with respect to the clinical efficacy of these compounds is still under debate. GP IIb/IIIa-antagonists are the most effective inhibitors of platelet function and in high doses, may cause complete inhibition of platelet aggregation and maximum prolongation of bleeding time. The clinical efficacy of GP IIb/IIIa-antagonists for acute percutaneous coronary interventions and in the management of the acute coronary syndrome is established. Whether Abciximab and low-molecular weight intravenous compounds (Eptifibatide, Tirofiban, Lamifiban) are equipotent, remains to be demonstrated by controlled comparative studies. Orally active low-molecular-weight compounds (Sibrafiban, Xemilofiban and others) are currently undergoing clinical trials. Whether these substances are superior to oral aspirin and/or clopidogrel in long-term prevention of acute arterial vessel occlusions remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:43:15