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Titolo:
Acute fluoxetine treatment potentiates amphetamine hyperactivity and amphetamine-induced nucleus accumbens dopamine release: possible pharmacokineticinteraction
Autore:
Sills, TL; Greenshaw, AJ; Baker, GB; Fletcher, PJ;
Indirizzi:
Clarke Inst Psychiat, Biopsychol Sect, Toronto, ON M5T 1R8, Canada Clarke Inst Psychiat Toronto ON Canada M5T 1R8 oronto, ON M5T 1R8, Canada Univ Alberta Hosp, Dept Psychiat, Neurochem Res Unit, Edmonton, AB T6G 2R7, Univ Alberta Hosp Edmonton AB Canada T6G 2R7 Unit, Edmonton, AB T6G 2R7,
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 141, anno: 1999,
pagine: 421 - 427
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; SEROTONIN REUPTAKE INHIBITORS; RECEPTOR ANTAGONIST; RAT; COCAINE; BRAIN; METABOLISM; NEURONS; LESIONS; SYSTEM;
Keywords:
SSRI; cytochrome P450; serotonin; microdialysis; norfluoxetine; locomotor activity; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Sills, TL Clarkenadat Psychiat, Biopsychol Sect, 250 Coll St, Toronto, ON M5T 1R8, Ca Clarke Inst Psychiat 250 Coll St Toronto ON Canada M5T 1R8 8, Ca
Citazione:
T.L. Sills et al., "Acute fluoxetine treatment potentiates amphetamine hyperactivity and amphetamine-induced nucleus accumbens dopamine release: possible pharmacokineticinteraction", PSYCHOPHAR, 141(4), 1999, pp. 421-427

Abstract

Amphetamine stimulates locomotor activity, in large part by activating central dopaminergic systems. Serotonin shares on overlapping distribution with dopamine and has been shown to modulate dopaminergic function and dopamine-mediated behaviors. The present study examined whether increasing serotonergic function, via the selective serotonin reuptake inhibitor fluoxetine would alter the stimulatory effects of amphetamine on locomotor activity anddopamine overflow in the nucleus accumbens. In addition, the present studydetermined whether fluoxetine treatment would alter the metabolism of amphetamine. Results show that 5.0 mg/kg fluoxetine potentiated the locomotor activity induced by amphetamine (0.5-1.0 mg/kg), and enhanced the increased dopamine overflow in the nucleus accumbens induced by amphetamine. Fluoxetine treatment also resulted in a higher concentration of amphetamine in the CNS. Together, these findings indicate that acute fluoxetine treatment potentiates the locomotor stimulating and dopamine activating effects of amphetamine. Further, the results indicate that fluoxetine potentiates the effects of amphetamine by decreasing the metabolism of amphetamine, probably through inhibition of cytochrome P450 isozymes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:48:18