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Titolo:
alpha(2)-adrenoreceptor subtypes regulate ACTH and beta-endorphin secretions during stress in the rat
Autore:
Zelena, D; Kiem, DT; Barna, I; Makara, GB;
Indirizzi:
Hungarian Acad Sci, Inst Expt Med, H-1450 Budapest, Hungary Hungarian AcadSci Budapest Hungary H-1450 Med, H-1450 Budapest, Hungary
Titolo Testata:
PSYCHONEUROENDOCRINOLOGY
fascicolo: 3, volume: 24, anno: 1999,
pagine: 333 - 343
SICI:
0306-4530(199904)24:3<333:ASRAAB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; ALPHA-ADRENERGIC STIMULATION; GROWTH-HORMONE RELEASE; ADRENOCORTICOTROPIN SECRETION; PARAVENTRICULAR NUCLEUS; PITUITARY; CLONIDINE; RECEPTORS; PLASMA; BRAIN;
Keywords:
ether stress; clonidine; prazosin; methoxamine; oxymetazoline; WB-4101;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Makara, GB Hungarian Acad Sci, Inst Expt Med, POB 67, H-1450 Budapest, Hungary Hungarian Acad Sci POB 67 Budapest Hungary H-1450 est, Hungary
Citazione:
D. Zelena et al., "alpha(2)-adrenoreceptor subtypes regulate ACTH and beta-endorphin secretions during stress in the rat", PSYCHONEURO, 24(3), 1999, pp. 333-343

Abstract

The effect of different alpha(2)-adrenoreceptor subtype agonists and antagonists on adrenocorticotrop hormone (ACTH) and beta-endorphin release induced by ether stress was examined. Ether inhalation-induced ACTH and beta-endorphin increase was inhibited by ICV administration of 30 mu g but not 1 and 10 mu g clonidine (alpha(2)-adrenoreceptor agonist). ICV oxymetazoline (alpha(2A)-adrenoreceptor agonist; 1-10-30 mu g) or the alpha(1)-agonist methoxamine (100 mu g/rat) failed to inhibit the stress-induced rise. Pretreatment with the alpha(1)/alpha(2B,C)-antagonist prazosin (0.5 mg/kg, IP) prevented the effect of clonidine on the ether stress, while the alpha(1)/alpha(2A)-antagonist WB-4101 (0.5 mg/kg, IP) was unable to counteract the inhibitory effect of clonidine. Prazosin alone had no effect on the ether-induced plasma ACTH and beta-endorphin elevation. These results suggest that noradrenaline in the central nervous system may inhibit the stress-induced hypothalamo-pituitary-axis and pituitary beta-endorphin activation via alpha(2B,C)-adrenoceptor subtypes and prazosin may antagonize its effect on these receptors. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:43:54