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Titolo:
Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly pathway in Saccharomyces cerevisiae
Autore:
Altheim, BA; Schultz, MC;
Indirizzi:
Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 hem, Edmonton, AB T6G 2H7, Canada
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 4, volume: 96, anno: 1999,
pagine: 1345 - 1350
SICI:
0027-8424(19990216)96:4<1345:HMGTCC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-CONTROL; DIVISION CYCLE; YEAST; TRANSCRIPTION; ACETYLATION; DNA; H3; H4; COMPLEX; INVIVO;
Keywords:
yeast; chromatin assembly factor; nucleosome; H3; H4; remodeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Schultz, MC Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 n, AB T6G 2H7, Canada
Citazione:
B.A. Altheim e M.C. Schultz, "Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly pathway in Saccharomyces cerevisiae", P NAS US, 96(4), 1999, pp. 1345-1350

Abstract

We describe a replication-independent, cell cycle-regulated chromatin assembly pathway in budding yeast. The activity of this pathway is low in S phase extracts but is very high in G(2), M, and G(1) cell extracts, with peak activity in late M/early G(1). The cell cycle regulation of this pathway requires a specific pattern of posttranslational modification of histones H3 and/or H4, which is distinct for H3/H4 present in S phase versus M and G1 phase cell extracts. Histone H3/H4 modification is therefore important for the reciprocal control of replication-dependent and -independent chromatin assembly pathways during the cell cycle.

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Documento generato il 25/11/20 alle ore 07:05:40