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Titolo:
Conserved features of Y RNAs revealed by automated phylogenetic secondary structure analysis
Autore:
Farris, AD; Koelsch, G; Pruijn, GJM; van Venrooij, WJ; Harley, JB;
Indirizzi:
Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA Oklahoma Med Res Fdn Oklahoma City OK USA 73104 lahoma City, OK 73104 USA Univ Nijmegen, Dept Biochem, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands Dept Biochem, Nijmegen, Netherlands
Titolo Testata:
NUCLEIC ACIDS RESEARCH
fascicolo: 4, volume: 27, anno: 1999,
pagine: 1070 - 1078
SICI:
0305-1048(19990215)27:4<1070:CFOYRR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL CYTOPLASMIC RIBONUCLEOPROTEINS; HUMAN RO RIBONUCLEOPROTEIN; PRE-MESSENGER-RNA; 5S RIBOSOMAL-RNA; POLYMERASE-III; LA PROTEINS; AUTOANTIBODIES; BINDING; IDENTIFICATION; AUTOANTIGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Harley, JB Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA Oklahoma Med Res Fdn 825 NE 13th St Oklahoma City OK USA 73104
Citazione:
A.D. Farris et al., "Conserved features of Y RNAs revealed by automated phylogenetic secondary structure analysis", NUCL ACID R, 27(4), 1999, pp. 1070-1078

Abstract

Y RNAs are small 'cytoplasmic' RNAs which are components of the Ro ribonucleoprotein (RNP) complex. The core of this complex, which is found in the cell nuclei of higher eukaryotes as well as the cytoplasm, is composed of a complex between the 60 kDa Ro protein and Y RNAs, Human cells contain four distinct Y RNAs (Y1, Y3, Y4 and Y5), while other eukaryotes contain a variable number of Y RNA homologues, When detected in a particular species, the Ro RNP has been present in every cell type within that particular organism. This characteristic, along with its high conservation among vertebrates, suggests an important function for Ro RNP in cellular metabolism; however, this function has not yet been definitively elucidated. In order to identifyconserved features of Y RNA sequences and structures which may be directlyinvolved in Ro RNP function, a phylogenetic comparative analysis of Y RNAshas been performed. Sequences of Y RNA homologues from five vertebrate species have been obtained and, together with previously published Y RNA sequences, used to predict Y RNA secondary structures. A novel RNA secondary structure comparison algorithm, the suboptimal RNA analysis program, has been developed and used in conjunction with available algorithms to find phylogenetically conserved secondary structure models for Y1, Y3 and Y4 RNAs, Short, conserved sequences within the Y RNAs have been identified and are invariant among vertebrates, consistent with a direct role for Y RNAs in Ro function, A subset of these are located wholly or partially in looped regions in the Y3 and Y4 RNA predicted model structures, in accord with the possibility that these Y RNAs base pair with other cellular nucleic acids or are sites of interaction between the Ro RNP and other macromolecules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:11:27