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Titolo:
High-frequency intracellular invasion of epithelial cells by serotype M1 group A streptococci: M1 protein-mediated invasion and cytoskeletal rearrangements
Autore:
Dombek, PE; Cue, D; Sedgewick, J; Lam, H; Ruschkowski, S; Finlay, BB; Cleary, PP;
Indirizzi:
Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 robiol, Minneapolis, MN 55455 USA Univ Minnesota, Dept Cell Biol & Neuroanat, Minneapolis, MN 55455 USA UnivMinnesota Minneapolis MN USA 55455 roanat, Minneapolis, MN 55455 USA Univ British Columbia, Biotechnol Lab, Vancouver, BC V6T 1W5, Canada Univ British Columbia Vancouver BC Canada V6T 1W5 ver, BC V6T 1W5, Canada Univdaritish Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1W5, Cana Univ British Columbia Vancouver BC Canada V6T 1W5 ouver, BC V6T 1W5, Cana Univadaitish Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1W5, Can Univ British Columbia Vancouver BC Canada V6T 1W5 couver, BC V6T 1W5, Can
Titolo Testata:
MOLECULAR MICROBIOLOGY
fascicolo: 3, volume: 31, anno: 1999,
pagine: 859 - 870
SICI:
0950-382X(199902)31:3<859:HIIOEC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROUP-A STREPTOCOCCI; SURFACE PROTEIN; SALMONELLA-TYPHIMURIUM; BINDING PROTEIN; L-MONOCYTOGENES; PYOGENES; PHAGOCYTOSIS; ENTRY; EXPRESSION; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Cleary, PP Univ Minnesota, Dept Microbiol, Box 196 UMHC, Minneapolis, MN 55455 USA Univ Minnesota Box 196 UMHC Minneapolis MN USA 55455 55455 USA
Citazione:
P.E. Dombek et al., "High-frequency intracellular invasion of epithelial cells by serotype M1 group A streptococci: M1 protein-mediated invasion and cytoskeletal rearrangements", MOL MICROB, 31(3), 1999, pp. 859-870

Abstract

A clonal variant of serotype M1 group A streptococcus (designated M1inv(+)) has been linked to severe and invasive infections, including sepsis, necrotizing fasciitis and toxic shock: High frequency internalization of cultured epithelial cells by the M1inv(+) strain 90-226 is dependent upon the M1 protein. Invasion of HeLa cells was blocked by an anti-M1 antibody, invasion by an M1(-) strain (90-226 emm1::km) was greatly reduced, and latex beadsbound to M1 protein were readily internalized by HeLa cells. Beads coated with a truncated M1 protein were internalized far less frequently. Scanningelectron microscopy indicated that streptococci invade by a zipper-like mechanism, that may be mediated by interactions with host cell microvilli. Initially, internalized streptococci and streptococci undergoing endocytosis are associated with polymerized actin. Later in the internalization process, streptococcal-containing vacuoles are associated with the lysosomal membrane glycoprotein, LAMP-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:23:28