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Titolo:
N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage
Autore:
Mattioli-Belmonte, M; Gigante, A; Muzzarelli, RAA; Politano, R; De Benedittis, A; Specchia, N; Buffa, A; Biagini, G; Greco, F;
Indirizzi:
Univ Ancona, Fac Med, Inst Normal Human Morphol, I-60020 Ancona, Italy Univ Ancona Ancona Italy I-60020 al Human Morphol, I-60020 Ancona, Italy Univ Ancona, Ctr Innovat Biomat, Ancona, Italy Univ Ancona Ancona ItalyUniv Ancona, Ctr Innovat Biomat, Ancona, Italy Univ Ancona, Inst Biochem, Ancona, Italy Univ Ancona Ancona ItalyUniv Ancona, Inst Biochem, Ancona, Italy Univ Ancona, Orthoped Clin, Ancona, Italy Univ Ancona Ancona ItalyUniv Ancona, Orthoped Clin, Ancona, Italy Univ Bologna, Dept Gen Med, Bologna, Italy Univ Bologna Bologna ItalyUniv Bologna, Dept Gen Med, Bologna, Italy
Titolo Testata:
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
fascicolo: 1, volume: 37, anno: 1999,
pagine: 130 - 134
SICI:
0140-0118(199901)37:1<130:NCADAF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESENCHYMAL STEM-CELLS; CHONDROCYTES; COLLAGEN; DIFFERENTIATION; CHONDROGENESIS; HYALURONAN; CHITIN; JOINT;
Keywords:
chitosan; bone morphogenetic protein; articular cartilage lesions; drug carrier;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Mattioli-Belmonte, M Univncona,a, Fac Med, Inst Normal Human Morphol, Via Tronto 10-A, I-60020 A Univ Ancona Via Tronto 10-A Ancona Italy I-60020 0 A
Citazione:
M. Mattioli-Belmonte et al., "N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage", MED BIO E C, 37(1), 1999, pp. 130-134

Abstract

Bone morphogenetic protein (BMP), associated with N,N-dicarboxymethyl chitosan, is used to induce or facilitate the repair of articular cartilage lesions. This association is intended for the synergistic potentiation of the respective biological effects. Data show that BMP-7 enhances the in vivo proliferation of cells with chondrocytes phenotype in the articular environment, leading to partial healing of the articular surface of the lesions. N,N-dicarboxymethyl chitosan is found to be useful as a molecular carrier or drug delivery agent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:20:01