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Titolo:
DECREASED STRIATAL DOPAMINERGIC RESPONSIVENESS IN DETOXIFIED COCAINE-DEPENDENT SUBJECTS
Autore:
VOLKOW ND; WANG GJ; FOWLER JS; LOGAN J; GATLEY SJ; HITZEMANN R; CHEN AD; DEWEY SL; PAPPAS N;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT MED UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794
Titolo Testata:
Nature
fascicolo: 6627, volume: 386, anno: 1997,
pagine: 830 - 833
SICI:
0028-0836(1997)386:6627<830:DSDRID>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN; C-11 RACLOPRIDE; THALAMIC NUCLEUS; FRONTAL-LOBE; BINDING; PET; DRUGS; ADDICTION; RECEPTORS; ABUSERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
N.D. Volkow et al., "DECREASED STRIATAL DOPAMINERGIC RESPONSIVENESS IN DETOXIFIED COCAINE-DEPENDENT SUBJECTS", Nature, 386(6627), 1997, pp. 830-833

Abstract

Cocaine blocks the reuptake of dopamine, a neurotransmitter involved in the control of movement, cognition, motivation and reward. This leads to an increase in extracellular dopamine; the reinforcing effect ofcocaine is associated with elevated dopamine levels in the nucleus accumbens(1,2). But addiction to cocaine involves other effects, such ascraving, loss of control and compulsive drug intake; the role of the dopamine system in these effects is less well-understood. We thereforeused positron emission tomography (PET) to compare the responses of cocaine addicts and normal controls to intravenous methylphenidate, a drug that, like cocaine, causes an increase in synaptic dopamine(3). Addicts showed reduced dopamine release in the striatum, the brain region where tile nucleus accumbens is located, and also had a reduced 'high' relative to controls. In contrast, addicts showed an increased response to methylphenidate in the thalamus (a region that conveys sensoryinput to the cortex). This thalamic response was associated with cocaine craving and was not seen in control subjects. Thus, our findings challenge the notion that addiction involves an enhanced striatal dopamine response to cocaine and/or an enhanced induction of euphoria. Moreover, they suggest a participation of thalamic dopamine pathways in cocaine addiction, a possibility that merits further investigation.

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Documento generato il 07/04/20 alle ore 04:12:41