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Titolo:
SUBGENUAL PREFRONTAL CORTEX ABNORMALITIES IN MOOD DISORDERS
Autore:
DREVETS WC; PRICE JL; SIMPSON JR; TODD RD; REICH T; VANNIER M; RAICHLE ME;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,MALLINCKRODT INST RADIOL,DIV RADIOL SCI ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL & NEUROL SURG NEUROL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,MCDONNELL CTR STUDIES HIGHER BRAIN FUNCT ST LOUIS MO 63110
Titolo Testata:
Nature
fascicolo: 6627, volume: 386, anno: 1997,
pagine: 824 - 827
SICI:
0028-0836(1997)386:6627<824:SPCAIM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; UNIPOLAR DEPRESSION; GLUCOSE-METABOLISM; (H2O)-O-15; VALIDATION; VALIDITY; COMMON; RATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
W.C. Drevets et al., "SUBGENUAL PREFRONTAL CORTEX ABNORMALITIES IN MOOD DISORDERS", Nature, 386(6627), 1997, pp. 824-827

Abstract

Pathological disturbances of mood may follow a 'bipolar' course, in which normal moods alternate with both depression and mania, or a 'unipolar' course, in which only depression occurs(1-3). Both bipolar and unipolar disorders can be heritable illnesses associated with neurochemical, neuroendocrine and autonomic abnormalities. The neurobiological basis for these abnormalities has not been established(2,3). Using positron emission tomographic (PET) images of cerebral blood flow and rate of glucose metabolism to measure brain activity, we have now localized an area of abnormally decreased activity in the pre-frontal cortex ventral to the germ of the corpus callosum in both familial bipolar depressives and familial unipolar depressives. This decrement in activity was at least partly explained by a corresponding reduction in cortical volume(4) as magnetic resonance imaging (MRI) demonstrated reductions in the mean grey matter volume in the same area of 39 and 48% in the bipolar and unipolar samples, respectively. This region has previously been implicated in the mediation of emotional and autonomic responses to socially significant or provocative stimuli, and in the modulation of the neurotransmitter systems targeted by antidepressant drugs(3,5-10).

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Documento generato il 04/07/20 alle ore 20:49:02