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Titolo:
Controlled resuscitation for uncontrolled hemorrhagic shock
Autore:
Burris, D; Rhee, P; Kaufmann, C; Pikoulis, E; Austin, B; Eror, A; DeBraux, S; Guzzi, L; Leppaniemi, A;
Indirizzi:
Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA Uniformed Serv Univ Hlth Sci Bethesda MD USA 20814 Bethesda, MD 20814 USA WalterSAeed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 U Walter Reed Army Med Ctr Washington DC USA 20307 , Washington, DC 20307 U Univ Helsinki, Cent Hosp, Helsinki, Finland Univ Helsinki Helsinki Finland v Helsinki, Cent Hosp, Helsinki, Finland
Titolo Testata:
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
fascicolo: 2, volume: 46, anno: 1999,
pagine: 216 - 222
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTONIC SALINE DEXTRAN; FLUID RESUSCITATION; HYPOTENSIVE PATIENTS; VASCULAR INJURY; MODEL; SURVIVAL; VOLUME; SWINE; RATS; HYPOTHERMIA;
Keywords:
uncontrolled hemorrhage; resuscitation; hypertonic saline; vascular trauma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Burris, D Uniformed Serv Univ Hlth Sci, Dept Surg, 4301 Jones Bridge Rd, Bethesda, MD Uniformed Serv Univ Hlth Sci 4301 Jones Bridge Rd Bethesda MD USA 20814
Citazione:
D. Burris et al., "Controlled resuscitation for uncontrolled hemorrhagic shock", J TRAUMA, 46(2), 1999, pp. 216-222

Abstract

Objective: To test the hypothesis that controlled resuscitation can lead to improved survival in otherwise fatal uncontrolled hemorrhage. Methods: Uncontrolled hemorrhage was induced in 86 rats with a 25-gauge needle puncture to the infrarenal aorta. Resuscitation 5 minutes after injurywas continued for 2 hours with lactated Ringer's solution (LR), 7.3% hypertonic saline in 6% hetastarch (HH), or no fluid (NF). Fluids infused at 2 mL.kg(-1) min(-1) were turned on or off to maintain a mean arterial pressure(MAP) of 40, 80, or 100 mm Hg in six groups: NF, LR 40, LR 80, LR 100, HH 80, and HH 80. Blood loss was measured before and after 1 hour of resuscitation. Results: Survival was improved with fluids. Preresuscitation blood loss was similar in all groups, NF rats did not survive 4 hours. After 72 hours, LR 80 rats (80%) and HIT 40 rats (67%) showed improved survival over NF rats(0%) (p < 0.05). Rebleeding increased with MAP. Attempts to restore normalMAP (LR 100) led to increased blood loss and mortality. Conclusion: Controlled resuscitation leads to increased survival compared with no fluids or standard resuscitation, Fluid type affects results. Controlled fluid use should be considered when surgical care is not readily available.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:12:56