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Titolo:
Heart murmurs, valvular regurgitation and electrical disturbances in copper-deficient genetically hypertensive, hypertrophic cardiomyopathic rats
Autore:
Shiry, LJ; Medeiros, DM; Bonagura, JD; McCune, SA;
Indirizzi:
Ohio State Univ, Dept Human Nutr & Food Management, Columbus, OH 43210 USAOhio State Univ Columbus OH USA 43210 Management, Columbus, OH 43210 USA Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 i & Technol, Columbus, OH 43210 USA Columbia Univ, Dept Vet Med & Surg, Columbia, MO USA Columbia Univ Columbia MO USA niv, Dept Vet Med & Surg, Columbia, MO USA
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
fascicolo: 1, volume: 18, anno: 1999,
pagine: 51 - 60
SICI:
0731-5724(199902)18:1<51:HMVRAE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPEROXIDE-DISMUTASE; DIETARY COPPER; IRON; RESTRICTION; OXIDASE;
Keywords:
cardiac hypertrophy; electrocardiogram; SHHF/Mcc-fa(cp); cardiac murmurs; echocardiograms; valve regurgitation; copper-deficiency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Medeiros, DM OhioNeilte Univ, Dept Human Nutr & Food Management, 347 Campbell Hall,1787 Ohio State Univ 347 Campbell Hall,1787 Neil Ave Columbus OH USA 43210
Citazione:
L.J. Shiry et al., "Heart murmurs, valvular regurgitation and electrical disturbances in copper-deficient genetically hypertensive, hypertrophic cardiomyopathic rats", J AM COL N, 18(1), 1999, pp. 51-60

Abstract

Objective: Rats with a genetic tendency to develop hypertensive, hypertrophic cardiomyopathy were fed copper-deficient diets and their cardiac responses were investigated. Methods: Five male weanling rats of the Long-Evans and SHHF/Mcc-fa(cp) strains were randomly selected to receive diets containing either adequate quantities of copper (94.5 mu mol Cu/kg diet) or reduced quantities of copper (<15.8 mu mol Cu/kg diet) for 6 weeks, (n=5 within each group). Echocardiograms and electrocardiograms were recorded and analyzed at the end of the 6-week interval. Results: Electrocardiograms from copper deficient groups showed longer Q-Tintervals and increased QRS amplitudes than controls. Both the copper deficient and control SHHF groups demonstrated significant QRS complex prolongation compared to Long-Evans rats. Echocardiography analysis showed significant increases in left ventricular area, free wall dimension, and myocardialcross-sectional areas in rats fed a copper deficient diet. The frequency of systolic cardiac murmurs increased in copper deficient rats and were related to the presence of valvular regurgitation as determined from echocardiography. Discussion: However, the data do not suggest that a copper-deficient diet fed to a strain of rats genetically susceptible to heart disease later in life, hastens or worsens the onset of cardiac disease. The genetic predisposition and copper-deficient states exert independent effects upon the heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:25:24