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Titolo:
SCHISTOSOMA-MANSONI - RELATIONSHIP OF TUMOR-NECROSIS-FACTOR-ALPHA TO MORBIDITY AND COLLAGEN DEPOSITION IN CHRONIC EXPERIMENTAL-INFECTION
Autore:
ADEWUSI OI; NIX NA; LU XT; COLLEY DG; SECOR WE;
Indirizzi:
FERRIS STATE UNIV BIG RAPIDS MI 49307 MERTU,HHS,USEMB APO AA 34024 VANDERBILT UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL NASHVILLE TN 37240 CTR DIS CONTROL & PREVENT,DIV PARASIT DIS,NATL CTR INFECT DIS,PUBL HLTH SERV ATLANTA GA 30341
Titolo Testata:
Experimental parasitology
fascicolo: 2, volume: 84, anno: 1996,
pagine: 115 - 123
SICI:
0014-4894(1996)84:2<115:S-ROTT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-RESPONSES; PULMONARY FIBROSIS; FACTOR PLAYS; MICE; EGG; INFLAMMATION; ANTIBODY; DISEASE; SILICA; RNA;
Keywords:
SCHISTOSOMA MANSONI; TREMATODE; TUMOR NECROSIS FACTOR-ALPHA; HYPERSPLENOMEGALY SYNDROME; MODERATE SPLENOMEGALY SYNDROME; TUMOR NECROSIS FACTOR-ALPHA (TNF)ALPHA; AGE-MATCHED CONTROL; SOLUBLE SCHISTOSOME EGG ANTIGENS; CIRCULATING CATHODIC ANTIGEN; SCHISTOSOME WORM ANTIGENIC PREPARATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
O.I. Adewusi et al., "SCHISTOSOMA-MANSONI - RELATIONSHIP OF TUMOR-NECROSIS-FACTOR-ALPHA TO MORBIDITY AND COLLAGEN DEPOSITION IN CHRONIC EXPERIMENTAL-INFECTION", Experimental parasitology, 84(2), 1996, pp. 115-123

Abstract

Relationship of tumor necrosis factor-alpha to morbidity and collagendeposition in chronic experimental infection. Experimental Parasitology 84, 115-123. Chronic (20-week) Schistosoma mansoni infections in male CBA/J mice present as one of two pathophysiologic forms: severe hypersplenomegaly syndrome (HSS) or a less severe, moderate splenomegaly syndrome (MSS). HSS mice are cachectic (including anemia and hypertriglyceridemia) and exhibit high levels of periportal and perioval fibrosis. Because tumor necrosis factor-alpha (TNF-alpha) is associated withthe symptoms of cachexia, we measured TNF-alpha protein and mRNA levels in the Livers of infected and uninfected animals. TNF-alpha levels in liver homogenates from mice with acute infections (8-week) were high (mean +/- SEM; 41.0 +/- 1.6 ng/g tissue) and remained high in liversof HSS mice (41.8 +/- 3.0 ng/g tissue) while TNF-alpha levels in liver homogenates of MSS mice were significantly lower (27.9 +/- 2.0 ng/g tissue). Similarly, hepatic TNF-alpha mRNA levels from HSS mice were two- to threefold higher than those from MSS mice. Hydroxyproline levels in these animals were determined as a measure of collagen depositionand fibrosis and showed increased overall levels in the livers of HSSanimals. To investigate the progression of HSS development, hematocrit and serum triglyceride levels were followed over a 20-week period after infection. In mice that developed HSS, hematocrit levels decreasedsignificantly and progressively from Weeks 10 through 20. These same animals showed significant increases in serum triglycerides compared to 8-week-infected mice or the mice which developed MSS over the same time period. These results suggest that failure to downregulate hepaticproduction of TNF-alpha correlates with, and may contribute to, the development of liver fibrosis and HSS in experimental schistosomiasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:54:38