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Titolo:
Gender differences in protection from EAE induced by oral tolerance with apeptide analogue of MBP-Ac1-11
Autore:
Bebo, BF; Adlard, K; Schuster, JC; Unsicker, L; Vandenbark, AA; Offner, H;
Indirizzi:
Dept Vet Affairs Med Ctr, Portland, OR 97201 USA Dept Vet Affairs Med CtrPortland OR USA 97201 tr, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Neurol, Portland, OR USA Oregon Hlth Sci Univ Portland OR USA Univ, Dept Neurol, Portland, OR USA Oregon Hlth Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR USA Oregon Hlth Sci Univ Portland OR USA crobiol & Immunol, Portland, OR USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 4, volume: 55, anno: 1999,
pagine: 432 - 440
SICI:
0360-4012(19990215)55:4<432:GDIPFE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; COLLAGEN-INDUCED ARTHRITIS; GROWTH-FACTOR-BETA; MULTIPLE-SCLEROSIS; II COLLAGEN; SUPPRESSION; DISEASE; ANTIGEN;
Keywords:
EAE/MS; oral tolerance; cytokines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Offner, H Deptortland,airs Med Ctr, Neuroimmunol Res R&D 31,3710 SW US VetHosp Rd, P Dept Vet Affairs Med Ctr Neuroimmunol Res R&D 31,3710 SW US VetHosp Rd Portland OR USA 97201
Citazione:
B.F. Bebo et al., "Gender differences in protection from EAE induced by oral tolerance with apeptide analogue of MBP-Ac1-11", J NEUROSC R, 55(4), 1999, pp. 432-440

Abstract

Mechanisms that contribute to increased female susceptibility to multiple sclerosis can be studied in the murine model of experimental autoimmune ecephalomyelitis (EAE), In this report, we compared oral tolerance induction in male and female B10.PL mice using fed myelin basic protein (MBP) Acl-ll peptide or a high-affinity analogue, Ac1-11[4Y]. We found that fed Ac1-11[4Y] peptide, but not native Ad-Il, could limit cellular infiltration into thecentral nervous system (CNS) and protect mate mice from EAE, an effect that was completely obviated by castration, In contrast, female mice could notbe orally tolerized or protected from EAE with either peptide, Tolerance induction in males was reflected by the appearance of Ac1-11[4Y]-reactive splenocytes that produced a sharply increased ratio of transforming growth factor (TGF)-beta:interleukin (IL)-2 and induced bystander suppression. Thesedata directly demonstrate gender differences in regulatory T cells, and support the concept that androgens are involved in governing oral tolerance to EAE. J. Neurosci. Res. 55:432-440, 1999. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 03/12/20 alle ore 12:14:54