Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of ibotenate hippocampal and extrahippocampal destruction on delayed-match and -nonmatch-to-sample behavior in rats
Autore:
Hampson, RE; Jarrard, LE; Deadwyler, SA;
Indirizzi:
Wake7Forest Univ, Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 2715 Wake Forest Univ Winston Salem NC USA 27157 macol, Winston Salem, NC 2715 Washington & Lee Univ, Dept Psychol, Lexington, VA 24450 USA Washington & Lee Univ Lexington VA USA 24450 hol, Lexington, VA 24450 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 19, anno: 1999,
pagine: 1492 - 1507
SICI:
0270-6474(19990215)19:4<1492:EOIHAE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
WORKING-MEMORY DEFICITS; IMPAIRMENT FOLLOWING LESIONS; ENTORHINAL CORTEX; PERIRHINAL CORTEX; PARAHIPPOCAMPAL CORTICES; PARTIAL-REINFORCEMENT; POSTRHINAL CORTICES; VISUAL RECOGNITION; OBJECT RECOGNITION; NONSPATIAL STIMULI;
Keywords:
ibotenate lesion; hippocampus; subiculum; entorhinal cortex; delay tasks; memory; training;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Hampson, RE WakeSalem,t Univ, Sch Med, Dept Physiol & Pharmacol, Med Ctr Blvd, Winston Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 nston
Citazione:
R.E. Hampson et al., "Effects of ibotenate hippocampal and extrahippocampal destruction on delayed-match and -nonmatch-to-sample behavior in rats", J NEUROSC, 19(4), 1999, pp. 1492-1507

Abstract

The effects of ibotenate lesions of the hippocampus (HIPP) or hippocampus plus collateral damage to extrahippocampal structures (HCX) were investigated in rats trained to criterion on spatial versions of either a delayed-match (DMS) or delayed-nonmatch-to-sample (DNMS) task. After recovery from surgery, animals were retrained at "0" sec delays, then assessed at 0-30 sec delays for 15 d, retrained again at 0 sec delays, and retested for another 25 d on 0-30 sec delays. Pretrained HIPP lesioned animals showed marked delay-dependent deficits in both tasks that never recovered. Detailed examination of within- and between-trial performance factors, including changes in response preferences, length of previous trial delay, and sequential dependencies, revealed important factors operating in lesioned animals that were either absent or insignificant before the lesion. Pretrained HCX-lesioned animals showed deficits similar to those of HIPP animals, with the noticeableexception of a strong "recency" influence of the previous trial. Another group of HIPP- and HCX-lesioned animals trained on the tasks after the lesion showed reduced impairments of the type described above, suggesting that extrahippocampal structures trained after the lesion can assume the role of the hippocampus to some degree. The findings indicate that both the type oflesion and the previous history of the animal determine the postlesion DMSand DNMS performance of animals suffering damage to the hippocampus and/orrelated structures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:38:09