Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The organization of cerebellar and basal ganglia outputs to primary motor cortex as revealed by retrograde transneuronal transport of herpes simplex virus type 1
Autore:
Hoover, JE; Strick, PL;
Indirizzi:
Vet Affairs Med Ctr, Res Serv, Syracuse, NY 13210 USA Vet Affairs Med CtrSyracuse NY USA 13210 es Serv, Syracuse, NY 13210 USA Millersville Univ, Dept Biol, Millersville, PA 17551 USA Millersville Univ Millersville PA USA 17551 l, Millersville, PA 17551 USA SUNY Hlth Sci Ctr, Dept Neurosurg, Syracuse, NY 13210 USA SUNY Hlth Sci Ctr Syracuse NY USA 13210 Neurosurg, Syracuse, NY 13210 USA SUNY Hlth Sci Ctr, Dept Neurosci, Syracuse, NY 13210 USA SUNY Hlth Sci Ctr Syracuse NY USA 13210 Neurosci, Syracuse, NY 13210 USA SUNY Hlth Sci Ctr, Dept Physiol, Syracuse, NY 13210 USA SUNY Hlth Sci CtrSyracuse NY USA 13210 t Physiol, Syracuse, NY 13210 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 19, anno: 1999,
pagine: 1446 - 1463
SICI:
0270-6474(19990215)19:4<1446:TOOCAB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; GLOBUS-PALLIDUS; MACAQUE MONKEY; PSEUDORABIES VIRUS; MACACA-MULATTA; PALLIDOTHALAMIC PROJECTIONS; NUCLEOCORTICAL PROJECTION; THALAMIC PROJECTIONS; EFFERENT CONNECTIONS; ANATOMICAL EVIDENCE;
Keywords:
primary motor cortex; cerebellum; basal ganglia; thalamus; transneuronal transport; herpes simplex virus; primate; motor control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Strick, PL Vet Affairs Med Ctr, Res Serv, 1515S, Syracuse, NY 13210 USA Vet Affairs Med Ctr 1515S Syracuse NY USA 13210 e, NY 13210 USA
Citazione:
J.E. Hoover e P.L. Strick, "The organization of cerebellar and basal ganglia outputs to primary motor cortex as revealed by retrograde transneuronal transport of herpes simplex virus type 1", J NEUROSC, 19(4), 1999, pp. 1446-1463

Abstract

We used retrograde transneuronal transport of herpes simplex virus type 1 to map the origin of cerebellar and basal ganglia "projections" to leg, arm, and face areas of the primary motor cortex (M1). Four to five days after virus injections into M1, we observed many densely labeled neurons in localized regions of the output nuclei of the cerebellum and basal ganglia. The largest numbers of these neurons were found in portions of the dentate nucleus and the internal segment of the globus pallidus (GPI). Smaller numbers of labeled neurons were found in portions of the interpositus nucleus and the substantia nigra pars reticulata. The distribution of neuronal labeling varied with the cortical injection site. For example, within the dentate, neurons labeled from leg M1 were located rostrally, those from face M1 caudally, and those from arm M1 at intermediate levels. In each instance, labeled neurons were confined to approximately the dorsal third of the nucleus. Within GPI, neurons labeled from leg M1 were located in dorsal and medial regions, those from face M1 in ventral and lateral regions, and those from arm M1 in intermediate regions. These results demonstrate that M1 is the target of somatotopically organized outputs from both the cerebellum and basal ganglia, Surprisingly, the projections to M1 originate from only 30% of thevolume of the dentate and <15% of GPI, Thus, the majority of the outputs from the cerebellum and basal ganglia are directed to cortical areas other than M1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:42:09