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Titolo:
Sustained and accelerating activity at two discrete sites generate epileptiform discharges in slices of piriform cortex
Autore:
Demir, R; Haberly, LB; Jackson, MB;
Indirizzi:
Univ Wisconsin, Sch Med, Dept Physiol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Physiol, Madison, WI 53706 USA Univ Wisconsin, Sch Med, Ctr Neurosci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Ctr Neurosci, Madison, WI 53706 USA Univ Wisconsin, Sch Med, Dept Anat, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Med, Dept Anat, Madison, WI 53706 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 19, anno: 1999,
pagine: 1294 - 1306
SICI:
0270-6474(19990215)19:4<1294:SAAAAT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRO-PHYSIOLOGICAL PROPERTIES; MAMMALIAN CEREBELLAR SLICES; VOLTAGE-SENSITIVE DYE; ENDOPIRIFORM NUCLEUS; DEEP NEURONS; RAT; POTENTIALS; RESPONSES; FEEDBACK; EPSPS;
Keywords:
epilepsy; voltage imaging; piriform cortex; olfactory cortex; disinhibition; neural circuitry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Jackson, MB Univ3706consin, Sch Med, Dept Physiol, SMI 129,1300 Univ Ave, Madison, WI 5 Univ Wisconsin SMI 129,1300 Univ Ave Madison WI USA 53706 WI 5
Citazione:
R. Demir et al., "Sustained and accelerating activity at two discrete sites generate epileptiform discharges in slices of piriform cortex", J NEUROSC, 19(4), 1999, pp. 1294-1306

Abstract

When near-threshold electrical stimulation is used to evoke epileptiform discharges in brain slices, a latent period of up to 150 msec elapses beforethe discharge begins. During this period most neurons are silent, and abnormal electrical activity is difficult to detect with microelectrodes. A fundamental question about epileptiform activity concerns how synchronous discharges arise abruptly in a relatively quiescent slice. This issue was addressed here by using voltage imaging techniques to study epileptiform discharges in rat piriform cortex slices. These experiments revealed two distinct forms of electrical activity during the latent period. (1) A steeply increasing depolarization, referred to here as onset activity, has been describedpreviously and occurs at the site of discharge onset. (2) A sustained depolarization that precedes onset activity, referred to here as plateau activity, has not been described previously. Plateau and onset activity occurred in different subregions of the endopiriform nucleus (a region of high seizure susceptibility). When cobalt or kynurenic acid was applied focally to inhibit electrical activity at the site of plateau activity, discharges were blocked. However, application of these agents to other nearby sites (exceptthe site of onset) failed to block discharges. Plateau activity representsa novel form of electrical activity that precedes and is necessary for epileptiform discharges. Discharges thus are generated in a sequential processby two spatially distinct neuronal circuits, The first circuit amplifies and sustains activity initiated by the stimulus, and the second generates the actual discharge in response to an excitatory drive from the first.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:41:40