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Titolo:
Activation of stress-activated protein kinases correlates with neurite outgrowth induced by protease inhibition in PC12 cells
Autore:
Giasson, BI; Bruening, W; Durham, HD; Mushynski, WE;
Indirizzi:
McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 chem, Montreal, PQ H3G 1Y6, Canada McGill Univ, Montreal Neurol Inst, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 Inst, Montreal, PQ H3G 1Y6, Canada McGill Univ, Dept Neurol Neurosurg, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 surg, Montreal, PQ H3G 1Y6, Canada
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 3, volume: 72, anno: 1999,
pagine: 1081 - 1087
SICI:
0022-3042(199903)72:3<1081:AOSPKC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; HEAT-SHOCK PROTEIN; P38 MAP KINASE; PHOSPHATIDYLINOSITOL 3-KINASE; ACTIN POLYMERIZATION; SIGNAL-TRANSDUCTION; TYROSINE KINASES; PC-12 CELLS; RAS; PHOSPHORYLATION;
Keywords:
neurite elongation; stress-activated protein kinase; proteasome inhibitors; PC12 cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Mushynski, WE McGill Univ, Dept Biochem, 3655 Drummond St,Room 914, Montreal, PQ H3G 1Y6, McGill Univ 3655 Drummond St,Room 914 Montreal PQ Canada H3G 1Y6
Citazione:
B.I. Giasson et al., "Activation of stress-activated protein kinases correlates with neurite outgrowth induced by protease inhibition in PC12 cells", J NEUROCHEM, 72(3), 1999, pp. 1081-1087

Abstract

PC12 cells are well characterized for their ability to differentiate into neuronal-like cells when challenged with nerve growth factor. It has been reported that the calpain and proteasome inhibitor N-acetyl-Leu-Leu-norleucinal (CI) is also able to induce neurite outgrowth in PC12 cells. In this study, we report that the inhibitor of proteasomal chymotrypsin-like activity, carbobenzoxylle-Glu-(O-tert-butyl)-Ala-Leu-aldehyde (PSI), can also induce differentiation of PC12 cells. Induction of neurite outgrowth with PSI, CI, or its close analogue, carbobenzoxy-leu-leu-leucinaI (MG132), was associated with stress-activated protein kinase (SAPK) activation. Neurite formation induced by protease inhibition was independent of mitogen-activated protein kinase/extracellular signal-regulated kinase, p38/reactivating kinase,or phosphatidylinositol 3-kinase activities. The exact mechanism by which protease inhibition activates SAPKs remains to be elucidated; however, our results suggest that the SAPK signal transduction cascade may be an alternative and/or parallel pathway in the regulation of neuronal differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:18:42