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Titolo:
Gabapentin in the treatment of refractory partial epilepsy in children with intellectual disability
Autore:
Mikati, MA; Choueri, R; Khurana, DS; Riviello, J; Helmers, S; Holmes, G;
Indirizzi:
Amer Univ Beirut, Dept Pediat, New York, NY 10022 USA Amer Univ Beirut New York NY USA 10022 ept Pediat, New York, NY 10022 USA Amer Univ Beirut, Pediat Epilepsy Program, New York, NY 10022 USA Amer Univ Beirut New York NY USA 10022 sy Program, New York, NY 10022 USA Harvard Univ, Sch Med, Childrens Hosp, Dept Neurol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hosp, Dept Neurol, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
, volume: 42, anno: 1998, supplemento:, 1
pagine: 57 - 62
SICI:
0964-2633(199812)42:<57:GITTOR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTIAL SEIZURES; DOUBLE-BLIND; THERAPY;
Keywords:
attention deficit; behavioural side-effects; gabapentin; partial seizures; MR; ID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Mikati, MA AmerSAniv Beirut, Dept Pediat, 18th Floor,850 3rd Ave, New York, NY 10022 U Amer Univ Beirut 18th Floor,850 3rd Ave New York NY USA 10022 U
Citazione:
M.A. Mikati et al., "Gabapentin in the treatment of refractory partial epilepsy in children with intellectual disability", J INTEL DIS, 42, 1998, pp. 57-62

Abstract

Twenty-six children with intellectual disability and six normal children, all suffering from refractory partial seizures, received open-label gabapentin (range= 10-50 mg kg(-1) day(-1); mean = 26.7 mg kg(-1) day(-1)) as an add-on medication to their antiepileptic drug regimen. Mean seizure frequency during baseline was 9.5 seizures per week. Both groups had a significant reduction in seizure frequency. Response scores and response ratios did notdiffer between the intellectually disabled and normal groups (1.67 +/- 0.67 and 1.25 +/- 0.69, P= 0.697, and -0.400 +/- 0.089 and -0.283 +/- 0.159, P= 0.961, respectively). Behavioural side-effects were more likely to occur in patients with intellectual disability in comparison with the mentally normal group (P= 0.0107). in the present patient population, patients youngerthan 10 years of age, all of whom had intellectual disability, were more likely to have side-effects than those older than 10 years of age. Observed adverse effects, which were generally mild, occurred in patients with baseline intellectual disability, attention deficit disorder and behavioural problems. Behavioural adverse effects warranted discontinuation of the medication in only three patients. The severity of intellectual disability (mild versus moderate or severe) did not affect the extent of the response or the occurrence of side-effects. It is concluded that gabapentin is equally effective as an add-on medication against partial seizures in patients with or without intellectual disability. However, children with intellectual disability who also are less than 10 years of age with baseline attention deficitappear to be at a higher risk of behavioural side-effects.

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Documento generato il 31/03/20 alle ore 07:40:33