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Titolo:
Dissecting NK cell development using a novel alymphoid mouse model: Investigating the role of the c-abl proto-oncogene in murine NK cell differentiation
Autore:
Colucci, F; Soudais, C; Rosmaraki, E; Vanes, L; Tybulewicz, VLJ; Di Santo, JP;
Indirizzi:
Hop Necker Enfants Malad, INSERM, U429, F-75015 Paris, France Hop Necker Enfants Malad Paris France F-75015 429, F-75015 Paris, France Natl Inst Med Res, London NW7 1AA, England Natl Inst Med Res London England NW7 1AA ed Res, London NW7 1AA, England
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 5, volume: 162, anno: 1999,
pagine: 2761 - 2765
SICI:
0022-1767(19990301)162:5<2761:DNCDUA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; TYROSINE KINASE; B-CELL; MICE; LYMPHOCYTE; BINDING; CYCLE; REJECTION; CHAIN; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Di Santo, JP HopF-75015 Enfants Malad, INSERM, U429, Pavillon Kirmisson,149 Rue Sevres, Hop Necker Enfants Malad Pavillon Kirmisson,149 Rue Sevres Paris France F-75015
Citazione:
F. Colucci et al., "Dissecting NK cell development using a novel alymphoid mouse model: Investigating the role of the c-abl proto-oncogene in murine NK cell differentiation", J IMMUNOL, 162(5), 1999, pp. 2761-2765

Abstract

NK lymphocytes participate in both innate and adaptive immunity by their prompt secretion of cytokines including IFN-gamma, which activates macrophages, and by their ability to lyse virally infected cells and tumor cells without prior sensitization. Although these characteristics of NK cells are well documented, little is known about the genetic program that orchestrates NK development or about the signaling pathways that trigger NK effector functions. By crossing NK-deficient common gamma-chain (gamma(c)) and recombinase activating gene (RAG)-2 mutant mice, we have generated a novel alymphoid (B-, T-, and NK-) mouse strain (RAG2/gamma(c)) suitable for NK complementation in vivo. The role of the c-abl proto-oncogene in murine NK cell differentiation has been addressed in hemopoietic chimeras generated using RAG2/gamma(c), mice reconstituted with c-abl(-/-) fetal liver cells. The phenotypically mature NK cells that developed in the absence of c-abl were capableof lysing tumor targets, recognizing "missing self," and performing Ab-dependent cellular cytotoxicity. Taken together, these results exclude any essential role for c-abl in murine NK cell differentiation in vivo. The RAG2/gamma(c) model thereby provides a novel approach to establish a genetic map of NK cell development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:10:58