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Titolo:
Cutting edge: A role for the adaptor protein LAT in human NK cell-mediatedcytotoxicity
Autore:
Jevremovic, D; Billadeau, DD; Scoon, RA; Dick, CJ; Irvin, BJ; Zhang, WG; Samelson, LE; Abraham, RT; Leibson, PJ;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 unol, Rochester, MN 55905 USA NIH,2Sect Lymphocyte Signaling, Cell Biol & Metab Branch, Bethesda, MD 2089 NIH Bethesda MD USA 20892 ng, Cell Biol & Metab Branch, Bethesda, MD 2089
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 5, volume: 162, anno: 1999,
pagine: 2453 - 2456
SICI:
0022-1767(19990301)162:5<2453:CEARFT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; TYROSINE PHOSPHORYLATION; ACTIVATION; COMPLEX; KINASE; SLP-76; PHOSPHOPROTEIN; STIMULATION; RECOGNITION; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Leibson, PJ Mayo Clin & Mayo Fdn, Dept Immunol, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 USA
Citazione:
D. Jevremovic et al., "Cutting edge: A role for the adaptor protein LAT in human NK cell-mediatedcytotoxicity", J IMMUNOL, 162(5), 1999, pp. 2453-2456

Abstract

Stimulation of NK cell-mediated cytotoxicity involves the coupling of proximal Src and Syk family protein tyrosine kinases to downstream effecters. However, the mechanisms linking these second messenger pathways are incompletely understood. Here, we describe a key role for the LAT (p36) adaptor protein in human NK cell activation. LAT is tyrosine phosphorylated upon stimulation of NK cells through Fc gamma RIII receptors and following direct contact with NK-sensitive target cells. This NK stimulation induces the association of LAT with several phosphotyrosine-containing proteins. In addition to the biochemical evidence showing LAT involvement in NK cell activation, a genetic model shows that LAT is required for FcR-dependent phosphorylation of phospholipase C-gamma. Furthermore, overexpression of LAT in NK cells leads to increased Ab-dependent cell-mediated cytotoxicity and "natural cytotoxicity," thus demonstrating a functional role for LAT in NK cells. Thesedata suggest that LAT is an important adaptor protein for the regulation of human NK cell-mediated cytotoxicity.

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Documento generato il 27/11/20 alle ore 07:31:32