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Titolo:
Sensitivity and specificity of dipstick tests for rapid diagnosis of malaria in nonimmune travelers
Autore:
Jelinek, T; Grobusch, MP; Schwenke, S; Steidl, S; von Sonnenburg, F; Nothdurft, HD; Klein, E; Loscher, T;
Indirizzi:
Univ Munich, Dept Infect Dis & Trop Med, D-80802 Munich, Germany Univ Munich Munich Germany D-80802 s & Trop Med, D-80802 Munich, Germany Humboldtrmany, Charite Campus Virchow Hosp, Med Clin Infect Dis, Berlin, Ge Humboldt Univ Berlin Germany chow Hosp, Med Clin Infect Dis, Berlin, Ge
Titolo Testata:
JOURNAL OF CLINICAL MICROBIOLOGY
fascicolo: 3, volume: 37, anno: 1999,
pagine: 721 - 723
SICI:
0095-1137(199903)37:3<721:SASODT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-FALCIPARUM MALARIA; POLYMERASE CHAIN-REACTION; ANTIGEN-CAPTURE ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Jelinek, T Univanynich, Dept Infect Dis & Trop Med, Leopoldstr 5, D-80802 Munich, Germ Univ Munich Leopoldstr 5 Munich Germany D-80802 2 Munich, Germ
Citazione:
T. Jelinek et al., "Sensitivity and specificity of dipstick tests for rapid diagnosis of malaria in nonimmune travelers", J CLIN MICR, 37(3), 1999, pp. 721-723

Abstract

Swift diagnosis of Plasmodium falciparum malaria in areas where the disease is not endemic is frequently complicated by the lack of experience on theside of involved laboratory personal. Diagnostic tools based on the dipstick principle for the detection of plasmodial histidine-rich protein 2 (HRP-2) and parasite-specific lactate dehydrogenase (pLDH), respectively, have become available for the qualitative detection of P, falciparum malaria. In order to evaluate two of the currently available assays, specimens from 231patients were screened during a prospective multicenter study. Among the screened specimens, samples from 53 patients (22.9%) were positive for P, falciparum malaria by microscopy and/or PCR. While the test kit based on the detection of HRP-2 performed with a sensitivity of 92.5% and a specificity of 98.3%, the kit for the detection of pLDH showed a sensitivity of 88.5% and a specificity of 99.4%. Dipstick tests have the potential of enhancing speed and accuracy of the diagnosis of P, falciparum malaria, especially if nonspecialized laboratories are involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:15:35