Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The reliability of medication inventory methods compared to serum levels of cardiovascular drugs in the elderly
Autore:
Smith, NL; Psaty, BM; Heckbert, SR; Tracy, RP; Cornell, ES;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Hlth Serv, Seattle, WA 98195 USA Univ Vermont, Dept Pathol, Colchester, VT USA Univ Vermont Colchester VT USA Vermont, Dept Pathol, Colchester, VT USA
Titolo Testata:
JOURNAL OF CLINICAL EPIDEMIOLOGY
fascicolo: 2, volume: 52, anno: 1999,
pagine: 143 - 146
SICI:
0895-4356(199902)52:2<143:TROMIM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION;
Keywords:
cardiovascular agents; drugs; epidemiologic methods; elderly;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, NL Cardiovasc,Hlth Res Unit, Metropolitan Pk,E Tower,Suite 1360,1730 Minor Ave Cardiovasc Hlth Res Unit Metropolitan Pk,E Tower,Suite 1360,1730 Minor Ave Seattle WA USA 98101
Citazione:
N.L. Smith et al., "The reliability of medication inventory methods compared to serum levels of cardiovascular drugs in the elderly", J CLIN EPID, 52(2), 1999, pp. 143-146

Abstract

Medication inventory is more reliable than self-report in assessing prescription drug use in elderly populations. it is not known how strongly medication inventory reflects actual medication use as measured by serum drug levels. In the Cardiovascular Health Study, medication data were collected annually by study interviewers from medication containers brought to the clinic visit. At the fourth clinic visit, venipuncture was performed under 12-hour fasting conditions. Participants were told to take medications as usual. Eased on medication inventory results, we randomly selected 55 users and 55 non-users oi four cardiovascular drugs: aspirin, propranolol, hydrochlorothiazide, and digoxin. All 110 blood samples for each of the four drugs were analyzed; cut points were based on detectable levels given laboratory limitations. Kappa statistics (K) tested degree of agreement between medication inventory findings and serum detection. Assays were completed on 400 samples (91%). Agreement for aspirin (n = 102) was poor: K = 0.16 (95% CI: 0.0-0.32). Agreement for propranolol (n = 98) was fair: K = 0.43 (95% CI: 0.27-0.59). Agreement for hydrochlorothiazide (n = 100) was good: K = 0.62 (95% CI: 0.53-0.91). Agreement for digoxin (n = 100) was excellent: K = 0.94 (95% CI: 0.74-1.0). For four all drugs, lack of agreement was confined primarily to participants who reported use but did not have detectable levels. Excluding aspirin users, only one non-user (0.7%) had drug detected in serum. The medication inventory is a reasonably sensitive and a fairly reliable method for ascertaining non-aspirin cardiovascular drug use in the elderly even though this method may overestimate use as assessed by serum level. J CLIN EPIDEMIOL 52;2:143-146, 1999. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:04:43