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Titolo:
Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal cortical bone
Autore:
Ma, YF; Jee, WSS; Yuan, ZZ; Wei, W; Chen, HK; Pun, SW; Liang, HH; Lin, CH;
Indirizzi:
Univ Utah, Sch Med, Div Radiobiol, Salt Lake City, UT 84112 USA Univ UtahSalt Lake City UT USA 84112 obiol, Salt Lake City, UT 84112 USA
Titolo Testata:
JOURNAL OF BONE AND MINERAL RESEARCH
fascicolo: 3, volume: 14, anno: 1999,
pagine: 439 - 448
SICI:
0884-0431(199903)14:3<439:PHAMUH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL STRUCTURAL ADAPTATIONS; REDEFINING WOLFF LAW; CANCELLOUS BONE; ANABOLIC ACTIONS; IMMOBILIZATION; MUSCLE; REMOBILIZATION; HISTOMORPHOMETRY; OSTEOPOROSIS; RECOVERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Ma, YF Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA Lilly Corp Ctr Indianapolis IN USA 46285 ndianapolis, IN 46285 USA
Citazione:
Y.F. Ma et al., "Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal cortical bone", J BONE MIN, 14(3), 1999, pp. 439-448

Abstract

Previous reports showed that bone mass and architecture only partially recovered by remobilization (RM) after immobilization (IM)-induced osteopenia,and that parathyroid hormone (PTH) had an anabolic effect on the skeleton. The aim of this study was to determine whether low doses of PTH could restore IM-induced cortical bone loss and whether a combination of PTH plus loading (RM) treatment would be more effective than the PTH in unloaded (IM) limbs. One hundred and sixty 6-month-old rats were divided into aging and IMgroups. The right hindlimb of the rat was immobilized by elastic bandage for 18 weeks, and then groups of rats were either kept IM or RM and treated with 30 mu g or 80 mu g of hPTH(1-38)kg/day for 2, 10, and 20 weeks. Fluorescent-labeled, undecalcified cross-sections of right tibial shafts were studied. We found that RM for 20 weeks after 18 weeks of IM only partially recovered IM-induced muscle weight loss and PTH had no effect on muscle weightin either IM or RM limbs; that RM for 20 weeks after 18 weeks of IM partially restored some minimal cortical width by stimulating periosteal and endocortical bone formation and decreasing endocortical resorption; that PTH treatment of IM limbs completely restored IM-induced cortical bone loss and added extra bone by stimulating bone formation indices on all bone surfaces and depressing bone resorption on endocortical surface; that PTH treatment of RM limbs produced similar anabolic effects as in IM limbs with 30 mu g/kg/day dose but the 80 mu g/kg/day dose-treated limbs had a higher periosteal bone formation rate, which created a larger cross-sectional area, more cortical bone area, and a thicker cortex than the same dose treated IM limbs;and that PTH 80 mu g/kg/day treatment produced more anabolic effect than the 30 mu g/kg/day in both IM and RM limbs. We concluded that reloading the hindlimb by RM after long-term IM could not recover the cortical bone mass,PTH at employed doses was able to completely restore IM-induced cortical bone loss, and this effect was independent of mechanical stimulation. However, when PTH was combined,vith mechanical loading (RM), a synergistic anabolic effect on periosteal bone formation occurred which increased the cross sectional area that can increase bone strength.

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Documento generato il 06/07/20 alle ore 08:16:23