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Titolo:
Smoking tobacco, microcirculatory changes and the role of nicotine
Autore:
Haustein, KO;
Indirizzi:
Univ Jena, Klin Pharmakol Erfurt, D-99089 Erfurt, Germany Univ Jena Erfurt Germany D-99089 armakol Erfurt, D-99089 Erfurt, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
fascicolo: 2, volume: 37, anno: 1999,
pagine: 76 - 85
SICI:
0946-1965(199902)37:2<76:STMCAT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED CORONARY VASOCONSTRICTION; BLOOD-CELL DEFORMABILITY; ISCHEMIC-HEART-DISEASE; HEALTHY-YOUNG ADULTS; CIGARETTE-SMOKING; RISK-FACTORS; TRANSDERMAL NICOTINE; PASSIVE SMOKING; CARDIOVASCULAR-DISEASE; AORTIC ENDOTHELIUM;
Keywords:
tobacco smoking; nicotine; diseases of the cardiovascular system; effects on the microcirculation; fibrinogen plasma level; carboxyhemoglobin; nicotine replacement therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Haustein, KO UnivyJena, Klin Pharmakol Erfurt, Nordhauser Str 78, D-99089 Erfurt, German Univ Jena Nordhauser Str 78 Erfurt Germany D-99089 t, German
Citazione:
K.O. Haustein, "Smoking tobacco, microcirculatory changes and the role of nicotine", INT J CL PH, 37(2), 1999, pp. 76-85

Abstract

Cigarette smoking has become a worldwide threat to the health of several million people. Even more frequently than the cancerogenic effect of tobaccosmoking, changes in the cardiovascular system occur in the form of coronary heart disease, hypertension, peripheral arterial occlusion disease and its lethal sequelae (apoplectic insult, myocardial infarction, cardiac insufficiency). Smoking - but not nicotine per se - represents a considerable pathological potential in its effects on microcirculatory processes, resultingin raised blood and plasma viscosity, reduced deformability of erythrocytes, raised leukocyte counts, activation of various coagulation factors (factor XII, von Willebrand factor), an increased tendency to thrombocyte aggregation and increased integration of fibrinogen in the vascular endothelium. Smoking is also partly responsible for activation of the adrenergic system. Measures to help smokers quit smoking are proposed along with methods for long-term application of nicotine preparations, in view of the fact that itis almost exclusively the products of combustion in smoking that are responsible for health damage, and not nicotine. The effects of the latter comprise mainly psychological and physical dependence. It is therefore necessaryfor physicians, national health scheme authorities, patients and politicians to rethink the matter of therapy for nicotine-dependent smokers. Every reduction of CO in the expiration air of the smoker, reflecting a reduction of CO-hemoglobin in the bloodstream, means progress in the sense of risk minimization (reinfarctions, apoplectic insults, progression of arteriosclerosis). This can be the beginning of a process of withdrawal that is more likely to meet with gradual acceptance by patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:55:40