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Titolo:
NEUROMODULATION OF MAST-CELLS IN HUMAN NA SAL-MUCOSA - HISTAMINE-RELEASE BY NEUROPEPTIDES IN-VITRO
Autore:
HANF G; SCHIERHORN K; BRUNNEE T; MATTHIAS C; KUNKEL G;
Indirizzi:
AUGUSTENBURGER PL 1 D-13353 BERLIN GERMANY HUMBOLDT UNIV BERLIN,VIRCHOW KLINIKUM,ABT KLIN IMMUNOL & ASTHMA POLIKLIN BERLIN GERMANY
Titolo Testata:
Allergologie
fascicolo: 3, volume: 20, anno: 1997,
pagine: 121 - 127
SICI:
0344-5062(1997)20:3<121:NOMIHN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
GER
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; GENE-RELATED PEPTIDE; SUBSTANCE-P; HUMAN-SKIN; ALLERGEN CHALLENGE; CO-EXISTENCE; AXON REFLEX; BLOOD-FLOW; RAT; SECRETION;
Keywords:
SUBSTANCE P; CALCITONIN GENE-RELATED PEPTIDE; VASOACTIVE INTESTINAL PEPTIDE; MAST CELLS; HISTAMINE; NASAL MUCOSA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
G. Hanf et al., "NEUROMODULATION OF MAST-CELLS IN HUMAN NA SAL-MUCOSA - HISTAMINE-RELEASE BY NEUROPEPTIDES IN-VITRO", Allergologie, 20(3), 1997, pp. 121-127

Abstract

There is growing evidence that neuropeptides like substance P (SP), vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide(CGRP) are involved in neurogenic inflammation of the nose, especially in allergic rhinitis. These neuropeptides induce effects on nasal epithelial, endothelial, immunological, inflammatory and glandular cells. It is known that SP, CGRP and VIP stimulate isolated rat and human mast cells to release histamine and lead to a wheal and flare reaction in the human skin. These observations together with the fact that peripheral nerve fibres are found in close proximity to mast cells leads to the idea that some of the effects of neuropeptides are mediated by histamine release as consequence of a functional nerve/mast cell interaction in human nasal mucosa. Thus we investigated the influence of SP,VIP, CGRP and calcium ionophore A23187 on histamine release of human nasal mucosa, using an in vitro short-term organ culture system. Compared to controls the histamine content in the culture supernatant of mucosal tissue samples stimulated with SP (10(-5), p < 0.01) and with calcium ionophore A231S7 (10(-5) M, p < 0.001) was significantly higher. This effect of SP could not be inhibited by cromolyn sodium (2 x 10(-4)M) or dexamethasone (10(-5)M). CGRP(10(-8) - 10(-6)M) and VIP (10(-8) - 10(-6)M) showed no influence on histamine release compared to controls. The results obtained in this study support the hypothesis of a neuromodulation by neuropeptides on mast cells and suggest that the interaction between sensory nerve fibres and mast cells are of pathogenetic importance in inflammation of human nasal mucosa.

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Documento generato il 24/11/20 alle ore 13:22:08