Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mast cells are augmented in deep vein thrombosis and express a profibrinolytic phenotype
Autore:
Bankl, HC; Grossschmidt, K; Pikula, B; Bankl, H; Lechner, K; Valent, P;
Indirizzi:
Univ Vienna, Dept Clin Pathol, A-1090 Vienna, Austria Univ Vienna ViennaAustria A-1090 pt Clin Pathol, A-1090 Vienna, Austria Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Univ Vienna Vienna Austria A-1090 Hematol & Hemostaseol, A-1090 Vienna, Krankenhaus St Polten, Inst Clin Pathol, St Polten, Austria Krankenhaus StPolten St Polten Austria Clin Pathol, St Polten, Austria
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 2, volume: 30, anno: 1999,
pagine: 188 - 194
SICI:
0046-8177(199902)30:2<188:MCAAID>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR; AURICULAR THROMBOSIS; UROKINASE RECEPTOR; TRYPTASE; MICE; SUSCEPTIBILITY; INCREASE; DISEASE; CHYMASE; RISK;
Keywords:
deep vein thrombosis; mast cells; tissue-type plasminogen activator; fibrinolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Bankl, HC Univiaienna, Dept Clin Pathol, Wahringer Gurtel 18-20, A-1090 Vienna, Austr Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 Austr
Citazione:
H.C. Bankl et al., "Mast cells are augmented in deep vein thrombosis and express a profibrinolytic phenotype", HUMAN PATH, 30(2), 1999, pp. 188-194

Abstract

A number of recent data suggest that mast cells (MC) and their products are involved in the pathophysiology of thrombosis. In the current study, we have evaluated the number, distribution, and phenotype of MC in patients with deep vein thrombosis of the lower limb (DVT) (n = 15). Contralateral nonthrombosed limb veins served as control (CO). MC were examined by Giemsa staining and by immunohistochemistry using antibodies against tryptase, chymase, tissue-type plasminogen activator (tPA), urokinase (uPA), urokinase receptor (uPAR), and plasminogen activator inhibitors (PAI-1, PAI-2). We found an increase in the number of tryptase-positive MC in DVT compared with CO (DVT: 9.1 +/- 1.0 v CO: 4.7 +/- 0.6 MC/mm(2) P <.05). Most of these MC appeared to accumulate in the adventitia of the thrombosed veins, in vicinity ofthe vasa vasorum. In both DVT and CO, MC reacted with monoclonal antibodies to c-kit, tryptase, and chymase. MC also stained positive for tPA and urokinase receptor, but did not express detectable PAI-1 or PAI-2. As comparedwith CO, a decreased proportion of MC in DVT was found to stain positive for chymase and tPA. Together, our results show that MC increase in number in DVT and express a profibrinolytic phenotype. We hypothesize that MC and MC-derived profibrinolytic molecules play a role in the pathophysiology of DVT. HUM PATHOL 30:188-194. Copyright (C), 1999 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:52:04