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Titolo:
THIENOPYRIDONE ANTIBACTERIALS .1. A SYNTHESIS OF SOME ,4-DIHYDRO-4-OXOTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACIDS
Autore:
ELABADELAH MM; SABRI SS; ALASHQAR HA;
Indirizzi:
APPL SCI UNIV,FAC SCI,DEPT CHEM 1 AMMAN 11931 JORDAN
Titolo Testata:
Heterocycles
fascicolo: 2, volume: 45, anno: 1997,
pagine: 255 - 264
SICI:
0385-5414(1997)45:2<255:TA.ASO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-CARBOXYLIC ACIDS; AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Elabadelah et al., "THIENOPYRIDONE ANTIBACTERIALS .1. A SYNTHESIS OF SOME ,4-DIHYDRO-4-OXOTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACIDS", Heterocycles, 45(2), 1997, pp. 255-264

Abstract

A selected set of 7-alkyl-4-oxothieno[2,3-b]pyridine-5-carboxylic acids (7) and their methyl esters (6) were prepared by cyclization of therespective -N-alkylamino-2-(2,5-dichloro-3-thienoyl)acrylates (5) which, in turn, are accessible via methyl 3-(2,5-dichlorothien-3-yl)-3-oxopropanoate (3). Of the present series, the N-cyclopropyl derivative (7b) exhibited the highest potency against Escherichia coli (MIC = 0.5 mu g/ml).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:39:57