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Titolo:
Effects of cinnarizine on different experimentally induced oedemas
Autore:
Blazso, G; Razga, Z; Gabor, M;
Indirizzi:
Albert Szent Gyorgyi Med Univ, Inst Pharmacodynam, H-6701 Szeged, Hungary Albert Szent Gyorgyi Med Univ Szeged Hungary H-6701 6701 Szeged, Hungary Albert Szent Gyorgyi Med Univ, Inst Pathol, H-6701 Szeged, Hungary Albert Szent Gyorgyi Med Univ Szeged Hungary H-6701 6701 Szeged, Hungary
Titolo Testata:
FUNDAMENTAL & CLINICAL PHARMACOLOGY
fascicolo: 1, volume: 13, anno: 1999,
pagine: 91 - 95
SICI:
0767-3981(1999)13:1<91:EOCODE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE EAR EDEMA; H-1-RECEPTOR ANTAGONISTS; INFLAMMATORY RESPONSE; SUBSTANCE-P; CROTON-OIL; CAPSAICIN; MICE; INVOLVEMENT; MEDIATORS; SEROTONIN;
Keywords:
ear oedema; cinnarizine; skin irritants; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Gabor, M Albert701ent Gyorgyi Med Univ, Inst Pharmacodynam, Eotvos St 6,POB 121, H-6 Albert Szent Gyorgyi Med Univ Eotvos St 6,POB 121 Szeged Hungary H-6701
Citazione:
G. Blazso et al., "Effects of cinnarizine on different experimentally induced oedemas", FUN CL PHAR, 13(1), 1999, pp. 91-95

Abstract

Experiments with male mice (28-32 g) of the CFLP strain showed that cinnarizine in doses of 2.5, 5.0 or 10.0 mg kg(-1) significantly inhibited the extent of ear oedema induced by croton oil, capsaicin or dithranol, in a dose-dependent manner. In rats of the Wistar strain, oedema was induced in the hind paw by subplantar injection of carrageenin, and simultaneously by the application of croton oil to the inner surface of the ear. Preliminary cinnarizine treatment (5, 10 or 20 mg kg(-1)) inhibited the development of bothtypes of oedema, to a statistically significant extent, in a dose-dependent manner. (C) Elsevier, Paris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/11/18 alle ore 03:11:25