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Titolo:
The effect of N-nitro-L-arginine methyl ester on morphine-induced changes in the plasma corticosterone and testosterone levels in mice
Autore:
Budziszewska, B; Leskiewicz, M; Jaworska-Feil, L; Lason, W;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, Dept Endocrinol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 docrinol, PL-31343 Krakow, Poland
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 1, volume: 107, anno: 1999,
pagine: 75 - 79
SICI:
0947-7349(1999)107:1<75:TEONME>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; PRECIPITATED WITHDRAWAL SYNDROME; LEYDIG-CELL STEROIDOGENESIS; OXIDE SYNTHASE INHIBITORS; OPIOID WITHDRAWAL; DEPENDENT MICE; RAT; SECRETION; TOLERANCE; RECEPTORS;
Keywords:
morphine; corticosterone; testosterone; nitric oxide; L-NAME; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Lason, W Polishakow, Sci, Inst Pharmacol, Dept Endocrinol, 12 Smetna St, PL-31343 Kr Polish Acad Sci 12 Smetna St Krakow Poland PL-31343 PL-31343 Kr
Citazione:
B. Budziszewska et al., "The effect of N-nitro-L-arginine methyl ester on morphine-induced changes in the plasma corticosterone and testosterone levels in mice", EXP CL E D, 107(1), 1999, pp. 75-79

Abstract

Effects of the nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME, 30 mg/kg i.p.), on morphine-induced changes in the plasma corticosterone and testosterone levels were studied in male mice. Acute morphine administration (15 and 30 mg/kg i.p.) enhanced the corticosterone levelafter 1 and 2 hr (at a dose of 30 mg/kg only). A 4-day treatment with increasing doses of morphine, from 15 to 50 mg/kg i.p., increased the plasma corticosterone concentration at 2 hr after the last injection. Single administration of L-NAME (30 mg/kg i.p.) had no effect on the corticosterone level, whereas its repeated injections (30 mg/kg i.p., twice a day for four days) elevated the hormone concentration at 2 hr after the last dose. Pretreatment of mice with L-NAME enhanced the stimulatory effects of both acute and repeated morphine administration on the corticosterone level. D-NAME (30 mg/kg i.p.), an inactive form of the nitric oxide synthase inhibitor, had no effect on the morphine-induced changes in the corticosterone level. Acute morphine administration had no effect on the plasma testosterone level after1 or 2 hr, whereas repeated drug injections decreased the hormone concentration after 2 hr. Single or repeated L-NAME administration did not influence the testosterone level in either control or morphine-treated animals. Theabove results indicate that inhibition of nitric oxide synthase enhances the stimulatory effect of morphine on corticosterone secretion, but does notinfluence the inhibitory effect of repeated morphine on the plasma testosterone concentration in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:50:15