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Titolo:
Effects of chronic unilateral internal pudendal arterial occlusion on reactivity of isolated corpus cavernosum strips from rabbits
Autore:
Utkan, T; Sarioglu, Y; Utkan, NZ; Kurnaz, F; Yildirim, S;
Indirizzi:
Univ Kocaeli, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Univ Kocaeli Kocaeli Turkey TR-41900 Pharmacol, TR-41900 Kocaeli, Turkey Univ Cumhuriyet, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey Univ Cumhuriyet Sivas Turkey TR-58140 Pharmacol, TR-58140 Sivas, Turkey Univ Kocaeli, Fac Med, Dept Gen Surg, TR-41900 Kocaeli, Turkey Univ Kocaeli Kocaeli Turkey TR-41900 Gen Surg, TR-41900 Kocaeli, Turkey
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 367, anno: 1999,
pagine: 73 - 79
SICI:
0014-2999(19990212)367:1<73:EOCUIP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORPORAL VENOOCCLUSIVE DYSFUNCTION; CANINE PENILE ERECTION; NITRIC-OXIDE; IMPOTENT MEN; SMOOTH-MUSCLE; ANIMAL-MODEL; NONCHOLINERGIC NEUROTRANSMISSION; RELAXATION; RESPONSES; INSUFFICIENCY;
Keywords:
ischemia; corpus cavernosum; contraction; relaxation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Utkan, T Univ Kocaeli, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Univ Kocaeli Kocaeli Turkey TR-41900 , TR-41900 Kocaeli, Turkey
Citazione:
T. Utkan et al., "Effects of chronic unilateral internal pudendal arterial occlusion on reactivity of isolated corpus cavernosum strips from rabbits", EUR J PHARM, 367(1), 1999, pp. 73-79

Abstract

An animal model was developed to elucidate the effect of chronic obstruction of the internal pudendal artery on the responsiveness of the corpus cavernosum. In male albino rabbits, the internal pudendal artery was chronically ligated unilaterally with a silk tie and the occlusion was maintained for1 month. The control group was sham-operated. The reactivity of corpus cavernosum tissue from the ligated animals and the control animals was studiedin organ chambers. Unilateral chronic ligation of the internal pudendal artery caused an impaired contractile response to alpha-adrenoceptor stimulation with decreased E-m and pD(2) values and an impaired relaxant response to electrical field stimulation but resulted in a marked increase in the endothelium-dependent relaxant response to carbachol with an increased pD(2) value. However chronic obstruction of the pudendal artery had no effect on adenosine-, papaverine- and sodium nitroprusside-induced relaxant responses,and there was no change in agonist potency. These data indicate that altered penile hemodynamics have an effect on the reactivity of the corpus cavernosum and may contribute to the etiology of impotence. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:32:05