Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help
Autore:
Gulbranson-Judge, A; Tybulewicz, VLJ; Walters, AE; Toellner, KM; MacLennan, ICM; Turner, M;
Indirizzi:
Babraham Inst, Cellular Immunol Programme, Cambridge CB2 4AT, England Babraham Inst Cambridge England CB2 4AT amme, Cambridge CB2 4AT, England Univ Birmingham, Sch Med, Dept Immunol, Birmingham, W Midlands, England Univ Birmingham Birmingham W Midlands England ngham, W Midlands, England Natl Inst Med Res, London NW7 1AA, England Natl Inst Med Res London England NW7 1AA ed Res, London NW7 1AA, England
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 2, volume: 29, anno: 1999,
pagine: 477 - 487
SICI:
0014-2980(199902)29:2<477:DICSIV>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERMINAL CENTER FORMATION; SIGNAL-TRANSDUCTION MOLECULE; GTP EXCHANGE FACTOR; ANTIGEN RECEPTOR; IMMUNE-RESPONSES; CD40 LIGAND; ACTIVATION; GENE; CD19; PROTOONCOGENE;
Keywords:
lymphocyte; isotype switching; T cell-B cell collaboration; transgenic/knockout;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Gulbranson-Judge, A Babraham Inst, Cellular Immunol Programme, Cambridge CB2 4AT, England Babraham Inst Cambridge England CB2 4AT 4AT, England
Citazione:
A. Gulbranson-Judge et al., "Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help", EUR J IMMUN, 29(2), 1999, pp. 477-487

Abstract

Vav, a guanine nucleotide exchange factor for members of the Rho family ofsmall GTPases, is activated through engagement of B and T lymphocyte antigen receptors. It is important for establishing the signaling threshold of the TCR, as mice lacking Vav display defective thymocyte selection. Here, conventional B cells are shown to develop normally in Vav-deficient mice but these mice have few B-1 B cells. The threshold for inducing B cell proliferation through BCR engagement in vitro is greater in Vav-deficient B cells. Nevertheless, in vivo the mutant mice have normal antibody responses to haptenated Ficoll. In contrast, Vav(-/-) mice show defective class switching to IgG and germinal center formation when immunized with haptenated protein. Interestingly, this defect is reversed in chimeras where normal T cells are present. Antigen-specific proliferation of T cells in the T zone was found to be similar in wildtype and Vav(-/-) mice but the induction of IL-4 mRNA and switch transcripts was specifically impaired. These results suggest that defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:08:07