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Titolo:
Anti-V beta 8 antibodies induce and maintain staphylococcal enterotoxin B-triggered V beta 8(+) T cell anergy
Autore:
Aroeira, LS; Mouton, CG; Toran, JL; Ward, ES; Martinez-A, C;
Indirizzi:
Univd,utonoma Madrid, Dept Immunol & Oncol, Ctr Nacl Biotecnol, CSIC, Madri Univ Autonoma Madrid Madrid Spain ncol, Ctr Nacl Biotecnol, CSIC, Madri Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX USA Univ Texas Dallas TX USA xas, SW Med Ctr, Dept Microbiol, Dallas, TX USA
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 2, volume: 29, anno: 1999,
pagine: 437 - 445
SICI:
0014-2980(199902)29:2<437:AB8AIA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; IN-VIVO; DEFICIENT MICE; SUPERANTIGEN; ACTIVATION; RECEPTOR; DEATH; REPERTOIRES; PHENOTYPE;
Keywords:
anergy; T cell receptor; antibody; staphylococcal enterotoxin B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Aroeira, LS Inst,Pesquisas Nucl, TBR, Travessa R 400 Cidade Univ, BR-05508900 Sao Paulo Inst Pesquisas Nucl Travessa R 400 Cidade Univ Sao Paulo Brazil BR-05508900 BC
Citazione:
L.S. Aroeira et al., "Anti-V beta 8 antibodies induce and maintain staphylococcal enterotoxin B-triggered V beta 8(+) T cell anergy", EUR J IMMUN, 29(2), 1999, pp. 437-445

Abstract

The mechanism involved in the maintenance of staphylococcal enterotoxin B (SEB)-induced T cell anergy is poorly understood. We demonstrated earlier that B cells play an important role in the maintenance of SEE-induced T cellanergy in vivo and in vitro. Here, we demonstrate that B cells are not essential in SEE-induced T cell activation, but are important for the maintenance of T cell memory phenotype and anergy in vivo. Studying the activated Bcell repertoire, we observe that SEE treatment increases serum anti-V beta8 antibody titer as detected by enzyme-linked immunosorbent assay using soluble V beta 8 chains as antigens, and by staining of a V beta 8-expressingthymoma. These antibodies disappear gradually after immunization with SEE,whereas the capacity of the T cells to respond to SEE in vitro is restored. Anti-V beta 8 monoclonal antibody treatment causes V beta 8(+) T cell unresponsiveness to SEE in vitro (anergy), without affecting CD4V beta 8(+) T cell frequency. Together, these results suggest a new mechanism to explain the maintenance of SEE-induced T cell anergy, which is dependent on B cellsand on anti-V beta 8 antibody that specifically interacts with V beta 8(+)T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:30:40