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Titolo:
Antigen-induced elevation of immunoreactive endothelin-1 (ET-1) levels in ovalbumin-sensitized guinea pig airway tissue
Autore:
Kizawa, Y; Kotake, H; Kusama, T; Saito, K; Murakami, H;
Indirizzi:
Nihon Univ, Coll Pharm, Dept Physiol & Anat, Chiba 2748555, Japan Nihon Univ Chiba Japan 2748555 Dept Physiol & Anat, Chiba 2748555, Japan
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY
fascicolo: 2, volume: 122, anno: 1999,
pagine: 239 - 243
SICI:
1367-8280(199902)122:2<239:AEOIE
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; ET(B) RECEPTORS; VASOCONSTRICTOR PEPTIDE; ASTHMA; BRONCHUS; IRL-1620; CELLS; BRONCHOCONSTRICTOR; PROLIFERATION; CONTRACTIONS;
Keywords:
anaphylactic reaction; asthma; endothelin-1; epithelium; guinea pig; ovalbumin; phosphoramidon; sensitized animal; trachea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Murakami, H Nihon Univ, Coll Pharm, Dept Physiol & Anat, Chiba 2748555, Japan Nihon Univ Chiba Japan 2748555 & Anat, Chiba 2748555, Japan
Citazione:
Y. Kizawa et al., "Antigen-induced elevation of immunoreactive endothelin-1 (ET-1) levels in ovalbumin-sensitized guinea pig airway tissue", COMP BIOC C, 122(2), 1999, pp. 239-243

Abstract

Changes in the immunoreactive ET-I levels during the anaphylactic reactionof airway tissue from ovalbumin-sensitized guinea pigs were investigated. ET-l-immunoreactivity (ET-IR) was detected in the epithelial and smooth muscle layers of tracheal sections from normal guinea pigs and it was enhancedslightly by phosphoramidon (I mu M) treatment. The ET-IR level of the epithelial layer of ovalbumin-treated tissue from actively sensitized animals was slightly higher than that from normal animals, but it was enhanced markedly by phosphoramidon (1 mu M) treatment. Furthermore, the mean ET-IR levelof homogenates of antigen-treated tracheal tissues from sensitized guinea pigs (22.8 +/- 1.55 fmol mg(-1) protein, n = 5) was significantly higher than the corresponding normal level (12.3 +/- 1.21 fmol mg(-1) protein, n = 5). These results suggest that increased epithelial airway ET-1 levels contribute to the anaphylactic reaction of guinea pig airways. (C) 1999 ElsevierScience Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:37:16