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Titolo:
MUTATIONS OF THE BRCA1 AND BRCA2 GENES AND THE POSSIBILITIES FOR PREDICTIVE TESTING
Autore:
GAYTHER SA; PONDER BAJ;
Indirizzi:
ADDENBROOKES HOSP,CRC,HUMAN CANC GENET RES GRP,BOX 238,HILLS RD CAMBRIDGE CB2 2QQ ENGLAND
Titolo Testata:
Molecular medicine today
fascicolo: 4, volume: 3, anno: 1997,
pagine: 168 - 174
SICI:
1357-4310(1997)3:4<168:MOTBAB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER SUSCEPTIBILITY GENE; BREAST-CANCER; OVARIAN; POLYPOSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Gayther e B.A.J. Ponder, "MUTATIONS OF THE BRCA1 AND BRCA2 GENES AND THE POSSIBILITIES FOR PREDICTIVE TESTING", Molecular medicine today, 3(4), 1997, pp. 168-174

Abstract

Two cancer susceptibility genes, BRCA1 on chromosome 17q12-21 and BRCA2 on chromosome 13q12-13, are thought to be responsible for similar to 80% of families containing multiple cases of early-onset female breast cancer. Germline mutations of BRCA1 are also associated with ovarian cancer and mutations of BRCA2 are associated with an increased risk of male breast cancer, ovarian cancer, prostate cancer and pancreatic cancer. The recent isolation of both genes should make possible the identification of the genetic defect that predisposes affected individuals to breast and ovarian cancer and might lead to the use of genetic information for predictive testing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 17:22:18