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Titolo:
Olanzapine: a basic science update
Autore:
Bymaster, F; Perry, KW; Nelson, DL; Wong, DT; Rasmussen, K; Moore, NA; Calligaro, DO;
Indirizzi:
Elilis,ly & Co, Lilly Res Labs, Lilly Corp Ctr, Neurosci Res Div, Indianapo Eli Lilly & Co Indianapolis IN USA 46285 Ctr, Neurosci Res Div, Indianapo
Titolo Testata:
BRITISH JOURNAL OF PSYCHIATRY
, volume: 174, anno: 1999, supplemento:, 37
pagine: 36 - 40
SICI:
0007-1250(199902)174:<36:OABSU>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTORS IN-VIVO; C-FOS EXPRESSION; ANTIPSYCHOTIC-DRUGS; DOPAMINE NEURONS; SEROTONIN; BINDING; ANTAGONISM; FOREBRAIN; VITRO; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Bymaster, F Elilis,ly & Co, Lilly Res Labs, Lilly Corp Ctr, Neurosci Res Div, Indianapo Eli Lilly & Co Indianapolis IN USA 46285 i Res Div, Indianapo
Citazione:
F. Bymaster et al., "Olanzapine: a basic science update", BR J PSYCHI, 174, 1999, pp. 36-40

Abstract

Olanzapine, an atypical antipsychotic, has a broad receptor binding profile, which may account for its pharmacological effects in schizophrenia, fn vitro receptor binding studies showed a high affinity for dopamine D2, D-3 and D-4 receptors; all 5-HT2 receptor subtypes and the 5-HT6 receptor; muscarinic receptors, especially the M-1 subtype; and alpha(1)-adrenergic receptors. tn vivo studies showed that olanzapine had potent activity at D-2 and 5-HT2A receptors, but much less activity at D-1 and muscarinic receptors, and that it inhibited dopaminergic neurons in the A10 but not the A9 tract, suggesting that this agent will not cause extrapyramidal side-effects (EPS). Microdialysis studies showed that olanzapine increased the extracellular levels of norepinephrine and dopamine, but not 5-HT, in the prefrontal cortex, and increased extracellular dopamine levels in the neostriatum and nucleus accumbens, areas of the brain associated with schizophrenia, Studies ofgene expression showed that olanzapine 10 mg/kg also increased Fos expression in the prefrontal cortex, the dorsolateral striatum, and the nucleus accumbens. These findings are consistent with the effectiveness of olanzapineon both negative and positive symptoms and suggest that, with careful dosing, olanzapine should not cause EPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 15:18:26