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Titolo:
Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers
Autore:
Szabo, ST; de Montigny, C; Blier, P;
Indirizzi:
McGill Univ, Neurobiol Psychiat Unit, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 Unit, Montreal, PQ H3A 1A1, Canada
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 126, anno: 1999,
pagine: 568 - 571
SICI:
0007-1188(199902)126:3<568:MONNFB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT LOCUS-COERULEUS; BRAIN; 5-HYDROXYTRYPTAMINE; PROJECTIONS; INHIBITION; BLOCKADE; NUCLEUS;
Keywords:
antidepressant; noradrenaline; major depression; panic disorder; serotonin (5-HT); selective serotonin reuptake inhibitor (SSRI);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Szabo, ST McGill Univ, Neurobiol Psychiat Unit, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 real, PQ H3A 1A1, Canada
Citazione:
S.T. Szabo et al., "Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers", BR J PHARM, 126(3), 1999, pp. 568-571

Abstract

Using in vivo extracellular unitary recording, the effect of short term (2-day) and long-term (21-day) administration of the selective 5-HT reuptake inhibitor (SSRI) paroxetine (10 mg kg(-1) day(-1), s.c. using osmotic minipumps) was examined on the spontaneous tiring activity of locus coeruleus noradrenergic neurons. Long-term but not short-term treatment significantly decreased firing activity. Thus, it appears that enhancing 5-HT neurotransmission by sustained SSRI administration leads to a reduction of the firing rate of noradrenergic neurons. The SSRI paroxetine therefore alters the activity of noradrenergic neurons with a delay that is consistent with its therapeutic action in depression and panic disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:07:46